ID V5BAQ6_TRYCR Unreviewed; 602 AA.
AC V5BAQ6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Nucleolar GTP-binding protein 2 {ECO:0000256|RuleBase:RU364023};
GN ORFNames=TCDM_07022 {ECO:0000313|EMBL:ESS64754.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS64754.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS64754.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS64754.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- FUNCTION: GTPase that associates with pre-60S ribosomal subunits in the
CC nucleolus and is required for their nuclear export and maturation.
CC {ECO:0000256|RuleBase:RU364023}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|RuleBase:RU364023}.
CC -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2
CC subfamily. {ECO:0000256|RuleBase:RU364023}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS64754.1}.
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DR EMBL; AYLP01000080; ESS64754.1; -; Genomic_DNA.
DR AlphaFoldDB; V5BAQ6; -.
DR EnsemblProtists; ESS64754; ESS64754; TCDM_07022.
DR VEuPathDB; TriTrypDB:TCDM_07022; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01858; NGP_1; 1.
DR Gene3D; 1.10.1580.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR024929; GNL2_CP_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR InterPro; IPR012971; NOG2_N_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11089; GTP-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11089:SF9; NUCLEOLAR GTP-BINDING PROTEIN 2; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR Pfam; PF08153; NGP1NT; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU364023};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364023};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364023};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT DOMAIN 207..376
FT /note="CP-type G"
FT /evidence="ECO:0000259|PROSITE:PS51721"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 68732 MW; DA70BC1CBA161BF3 CRC64;
MGKPGKKAGK GLLPPTNVNR RVDANKTSLR DQRTIKRLKM YKSKLLRDEK GNIVKGSVLQ
ASDRVEQQMV RVAPDRRWFG NTRVIGQEAL QNFLKEMGSK YRDPYSIVIK QSKLPLSLLE
SSGTNKGSVR QQMEWEKTFG EKANRKRVRL DTVDIEGFAN RAVSKGEEYL TEKKGVDGNL
INKEENLRDD RSKNRILFKK GQSNRIWNEL YKVIDSSDVV LYILDARDPL GTRSSFLEEY
MRKEKKYKHF IFVLNKCDLV PLWATARWLQ VLSKDYPTVA FHASINHPFG KGSLISLLRQ
FAKLQNVTHR GSKRTKTPIS VGVIGYPNVG KSSLINTLRR KSVCKVAPIP GETKVWQYVA
LTKTIFLIDC PGVIYDRETN NDVQAVLKGV VRVERLGNAD KTDVVNTVLE IVKPKDIVAT
YGVSDWRDVN DFLEKLAKLR GKLVSGGQPD TEAASRMVLY DWQRGRIPWF SAPPFDSNKQ
YRDALELPEA KQMKLIEHYG TFNIVEGAMD HNEKSDEETL QNTCDFSGAD SFNEKQIQKS
KKETNINATV ASYMSEQIIL KKKEQRKRSK SEPAIKNSRA KETNNNYNDD DLWNRFLAAA
KK
//
