ID V5BB27_TRYCR Unreviewed; 724 AA.
AC V5BB27;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=tRNA (guanine(26)-N(2))-dimethyltransferase {ECO:0000256|ARBA:ARBA00039099};
DE EC=2.1.1.216 {ECO:0000256|ARBA:ARBA00039099};
GN ORFNames=TCDM_06905 {ECO:0000313|EMBL:ESS64889.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS64889.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS64889.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS64889.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Trm1 family. {ECO:0000256|PROSITE-ProRule:PRU00958}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS64889.1}.
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DR EMBL; AYLP01000077; ESS64889.1; -; Genomic_DNA.
DR AlphaFoldDB; V5BB27; -.
DR EnsemblProtists; ESS64889; ESS64889; TCDM_06905.
DR VEuPathDB; TriTrypDB:TCDM_06905; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0160102; F:tRNA (guanine(10)-N2)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006400; P:tRNA modification; IEA:UniProt.
DR Gene3D; 3.30.56.70; N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002905; Trm1.
DR InterPro; IPR042296; tRNA_met_Trm1_C.
DR PANTHER; PTHR10631; N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10631:SF3; TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE; 1.
DR Pfam; PF02005; TRM; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51626; SAM_MT_TRM1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU00958}; Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00958};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU00958};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00958}; tRNA processing {ECO:0000256|PROSITE-ProRule:PRU00958};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|PROSITE-
KW ProRule:PRU00958}.
FT REGION 423..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 79310 MW; 0522369BAE59186E CRC64;
MCTHEWAILP PQWDSVRLLV AAVELRWGGG KMRSGLFNAE GLAKEPVSGF EKITEGTAAV
LFPPANVKGS SASQHADCTK RQGDHRDADD IDDDGQAVFY NPVQVVNRDL SVCALACFSH
LRREEPRRKG GTRDGITILE ALSATGLRAI RYYNEVPGVR FIIANDLDPD AVACIRRNCE
FNGVPCARPT MTENFPPEGI RVDEATGVIE AGGAVIPNLD DANDLMFRLA ANSTVYAGRR
FCAVPSQMAN NITTSNGDVS VNEAQPLLQQ ELMDVVDLDP YGSASPFLDG AMRCIKEGGL
LLVTSTDSAI LCGGHPDTCH AKYNTIPTKN AACHEMAVRI LLAALERVAN KHRRYILPLL
SLHIDFYVRC FVRVYTQPAE VKLSPCKLGY LLQCSHCPAY WVRPMAVARM RDKKCARRKN
KMPNNDLLKS SISSGNNNDN NNINDASKSN DMGNDHVECK ADTLGRERFP AIPLRQENPK
ITSCSLRHML PCVNTHCCNV CGASLTLSGP IYAAPTHCVS FLLQLLQEVE RRGAAKQITA
EARVAGLVRL AMEELPDTPL FYQIPDIASF VKVRCPPTPK LVGALGRMGY RCSQVHCAPS
GLKTDCPPDV LVRVMLQWKR EQEQASGDAE KGSCDAAKAA VLSATAAEAI NEKAGEEEKR
GAGVFVLEPI DGADFSYDRR FAFRGVVTGV AKFIPNAPNW GPKRRHQGAM HNNDEQLTRK
QRKE
//