ID V5BCB8_TRYCR Unreviewed; 651 AA.
AC V5BCB8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 22-FEB-2023, entry version 31.
DE SubName: Full=Glucose-regulated protein 78 {ECO:0000313|EMBL:ESS63712.1};
GN ORFNames=TCDM_08367 {ECO:0000313|EMBL:ESS63712.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS63712.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS63712.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS63712.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|RuleBase:RU003322}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS63712.1}.
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DR EMBL; AYLP01000115; ESS63712.1; -; Genomic_DNA.
DR AlphaFoldDB; V5BCB8; -.
DR SMR; V5BCB8; -.
DR EnsemblProtists; ESS63712; ESS63712; TCDM_08367.
DR VEuPathDB; TriTrypDB:TCDM_08367; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd10241; HSPA5-like_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR042050; BIP_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR19375:SF144; ENDOPLASMIC RETICULUM CHAPERONE BIP; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..651
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004731344"
FT REGION 602..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 529..556
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 604..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 71346 MW; 3321776476C67957 CRC64;
MLLQALLVLS AVVVAVAAPD GTGKVEAPCV GIDLGTTYSV VGVWQKGDVH IIPNDMGNRI
TPSVVAFTET ERLIGDGAKN QLPQNPHNTI YAIKRLIGRK YSDTTVQTDK KLLSYEVVAD
KDGKPKVQVE VGGKKKQFTP EEVSAMVLQK MKEIAETYLG EKVKNAVVTV PAYFNDAQRQ
STKDAGTIAG LNVVRIINEP TAAAIAYGLN KAGEKNILVF DLGGGTFDVS LLTIDEGFFE
VVATNGDTHL GGEDFDNNMM RYFVDMLKKK KNVDVSKDQK ALARLRKACE AAKRQLSSHP
EARVEVDSLT EGFDFSEKIT RAKFEELNME LFKGTLVPVQ RVLEDAKLKK SDIHEIVLVG
GSTRVPKVQQ LIRDFFGGKE PNRGINPDEA VAYGAAVQAA VLTGESEVGG RVVLVDVIPL
SLGIETVGGV MTKLIERNTQ IPTKKSQVFS TYQDNQPGVL IQVYEGERQM TKDNRLLGKF
ELSGIPPAPR GVPQIEVTFD VDENSILQVS AVDKSSGKKE EITITNDKGR LSEEEIERMV
REAAEFEDED RKVRERVDAR NSLESVAYSL RNQVNDKEKL GGKLSADDKS AVEAAVKEAM
QFLDDNPNAD KEEYDEARDK LQSVTNPIIQ KVYQSGGGAD GDERPEPMDD L
//
