ID V5BD69_TRYCR Unreviewed; 666 AA.
AC V5BD69;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Threonine synthase {ECO:0000313|EMBL:ESS65639.1};
GN ORFNames=TCDM_05925 {ECO:0000313|EMBL:ESS65639.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS65639.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS65639.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS65639.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR604450-51};
CC -!- SIMILARITY: Belongs to the threonine synthase family.
CC {ECO:0000256|ARBA:ARBA00005517}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS65639.1}.
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DR EMBL; AYLP01000060; ESS65639.1; -; Genomic_DNA.
DR EnsemblProtists; ESS65639; ESS65639; TCDM_05925.
DR VEuPathDB; TriTrypDB:TCDM_05925; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.90.1380.10; Threonine synthase, N-terminal domain; 1.
DR InterPro; IPR029144; Thr_synth_N.
DR InterPro; IPR037158; Thr_synth_N_sf.
DR InterPro; IPR004450; Thr_synthase-like.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR00260; thrC; 1.
DR PANTHER; PTHR43515; THREONINE SYNTHASE-LIKE 1; 1.
DR PANTHER; PTHR43515:SF1; THREONINE SYNTHASE-LIKE 1; 1.
DR Pfam; PF00291; PALP; 1.
DR Pfam; PF14821; Thr_synth_N; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR604450-51};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT DOMAIN 102..184
FT /note="Threonine synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14821"
FT DOMAIN 240..552
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
FT MOD_RES 248
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR604450-51"
SQ SEQUENCE 666 AA; 74025 MW; FD1D198B875B3133 CRC64;
MFNLCVMGSA PATVKEQVER ALLAAYVPAR FMLTRLEDVK EREDHGRLLS QSFRLLLEAX
XXXDAPPTNP QGMPYDCRFF WTPESTTDEV VTEVKSLLDG RRFISTRGVV DMSTNFLSVV
RDGLAPNSGL FNLQSIPQMA MSQMRHFFTT SKLSYVEGAQ LVLERLVDTT MQPEKLRMLL
MEAYAPCRWS GLSDVCPVTP LLLDETDNNK AMDGHHHGAN KETGAAADPC WRDMSLMELY
HGPTAAFKDF ALQLFPRYFD IAASNECTDT PPSYVILTAT SGDTGVAAIS GFVNAGSPTR
VMVLYPLHGV SPVQQIQMLS YDNGASVRVY GVKSDFDFCQ STVKQLFAKR SLAQRLWSDK
KIRLSSANSI NWGRLVPQVA YYFWAYRQFV QKRRLQFGNP LDVVVPCGNF GNILAAFFAK
RMGLPLGKLV VASNCNDVLF EFVETGHYDI RQRHLVQTAS PSIDILKASN VERLLFLISN
GDAAFVAAQM HRLETEKHFN LQGDALNAMR DVFWSARCTE AECAATIKEV YEASAGRLLD
PHTAVAVFVA RQFRRFQLEK GLSHRPLVIA STAHWAKFPR SVLRALRGEE MAYGITTSVG
GQVNPVRACR ELYDEILTHC PGATVHPALN AALAAAEANA FSPREVEADV SRVEEELLQF
VSVNSA
//
