ID V5BEL1_TRYCR Unreviewed; 568 AA.
AC V5BEL1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 08-NOV-2023, entry version 25.
DE SubName: Full=GDP-mannose 4,6 dehydratase {ECO:0000313|EMBL:ESS64487.1};
GN ORFNames=TCDM_07387 {ECO:0000313|EMBL:ESS64487.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS64487.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS64487.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS64487.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS64487.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYLP01000088; ESS64487.1; -; Genomic_DNA.
DR EnsemblProtists; ESS64487; ESS64487; TCDM_07387.
DR VEuPathDB; TriTrypDB:TCDM_07387; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:InterPro.
DR GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR CDD; cd05246; dTDP_GD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 232..547
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 568 AA; 64764 MW; 654BCFB3218715DB CRC64;
MGRSHWRCCA GHRHVFFFVT SFLSDFFLFL FCAVTIALCS RGADGDRCYA LLPFVFEFIF
TRRSAPAAVC SWKRLSLSSR HKSVKRGALD MRLACRCWCV GEWEVKVQGK DLLVIFFKVV
IIEFVGGAFK MRISRVPAYV FVCVYVCVFL FYVPFDPLSL LSSRGWGGPC GRNRKAATIA
RFTQREASGI ADQLAPGRRG GRRGPTCMFR RPEDVECRRT RLTDTRPLRH LLVTGGLGFI
GSNFINHLMR THSGVHVYNL DKVDYCSSFR SIENPSDPHY HFVKGNITNA DLVMYVLRHH
DIDTIINFAA QSHVDNSFGN SLSFTYNNVL GTHVLLECAR TYGRIEKFIH VSTDEVYGQV
TDSKKEEGTL NPTNPYAATK AAVEYIVKSY HISFGLPCII TRGNNVYGPY QYPEKLIPRF
IMLMNAGKKL TIQGNGSNKR TFIHASDVAR AFVAIINHGF IGDVYNIGSC DEKSVLDIAR
MTVKYVQAHK CGERQPLADP SEEDVSRHLV FVKDREFNDE RYDISVEKLQ ELGWRQEVRF
EEGYKETVAW YLKAFAQEFW XXXXKNKI
//
