ID   V5BEP3_TRYCR            Unreviewed;       896 AA.
AC   V5BEP3;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS62903.1};
GN   ORFNames=TCDM_09371 {ECO:0000313|EMBL:ESS62903.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS62903.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS62903.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS62903.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS62903.1}.
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DR   EMBL; AYLP01000154; ESS62903.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5BEP3; -.
DR   EnsemblProtists; ESS62903; ESS62903; TCDM_09371.
DR   VEuPathDB; TriTrypDB:TCDM_09371; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   InterPro; IPR021287; Trans-sialidase_CS.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   Pfam; PF11052; Tr-sialidase_C; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        43..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          94..438
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          760..846
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..37
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        760..825
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        828..846
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   896 AA;  95315 MW;  80F162F9885E8816 CRC64;
     MLSRVAAVRA PRTHNRRRVT GSSGRRREGE ESERQRRNMS RHLFCSAVLL LVLVMVCCGT
     GGAAQDPEQA SEPKFEWKEV KDEDGDVTVE SLGAPGLLKV GSDVFAVAEV QCKDSQNTVF
     TGIASQLLTK TADKEPMEEV LKDAKEKTQV LEEFTSGKAE KVDVSRPTAV VTGSDIYMLV
     GKYNGEGDAA CQGEDGCGLF LLKGGVTGEG SSTKIGWTDT KRLPKNIFGE QLKSLTGLIG
     GGGSGVKITD DTLVLPVEGT KNGKAVSLII YSSDTNSWTL SKGMSADGCG VPSVVEWGEK
     DKLMMMTVCD DGRRRVYESG DKGESWTEAL GTLSRVWGNK HEGNVKGVRS GFSTATIGDG
     VDDDNKKNVM LVTLPVYLKE AHEENEEKEN EKGVLHLWLT DNTHIVDIGP VSGDDDAAAS
     SLLYRSGNNN EELIALYEKK KGDGKKPSPG MVSVRLTAQL KRVKEVLTTW KEVDERVSKL
     CPSENAKNDA PTATACSNTV KITDGLVGFL SGNFSGTTWK DEYLGVNATV TKEEGATVAT
     ENRDGVRFTG RGAWAEWPVG KQGDNQLYHF ANYNFTLVAT VSIDNLPEEG DTHTPLMGAK
     LNGDNNPVLV GLSYNNKEKK WILLCGGGEN KKYISDWETK KSEHVVILLR NGNQGSVYVD
     GQRVGGDEQC KLGNKDSKGI SHFYIGGSAE NTGTKEDVSV TVSNVLLYNR PLSSEEINTL
     NPNKAPIPPL VEVPTKPLTV SSASVVSPFP SVAAAAQIAG TSSTPAGTQQ TEREQPMGSS
     GAGSGGASTS AVSTVSTPSA EKHSVKQAAS GKSSDGAQTV DGGSTADGEP TMEKREGTDA
     QKEEVHPQVR EVNATALNSS LGHLSQGNNT DAGTVRGSGP LPSLLLLLGL WGFSAL
//