ID   V5BGR9_TRYCR            Unreviewed;       559 AA.
AC   V5BGR9;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN   ORFNames=TCDM_08515 {ECO:0000313|EMBL:ESS63633.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS63633.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS63633.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS63633.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS63633.1}.
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DR   EMBL; AYLP01000119; ESS63633.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5BGR9; -.
DR   EnsemblProtists; ESS63633; ESS63633; TCDM_08515.
DR   VEuPathDB; TriTrypDB:TCDM_08515; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   CDD; cd00821; PH; 1.
DR   Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR003409; MORN.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR23084:SF257; MORN REPEAT-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR23084; PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED; 1.
DR   Pfam; PF02493; MORN; 9.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00698; MORN; 10.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT   DOMAIN          427..543
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   559 AA;  62539 MW;  4262BCCCB9EFF155 CRC64;
     MGSGSQERFE GRLSSADGYV TNAQLPGNHV YTGEVSDDTM HGYGVLTTEL DVYTGNFYWN
     MRHGHGTFCS KVEKHPTGVR IYDGEWNMDE RQGIGSIQWC NGDTYNGPFL RGRPHGEMGS
     YNFADGRVYK GEYRHGVRHG IGRLTQKNGE YYEGEFKDGA MTGMGKGWYA GGKRVYEGTW
     ENGKKVRGKL TFEGSKRMYN GDWKHEKPHG AGEMIFANGD HYIGDFVMGK LHGTGSITYH
     SQGGKTYCGF FMENQPHGKG VLTMPDGSSV VGYFKHGIQL SENDSAAIEQ VIKETASLPH
     LFAHDDACST RSTPVQVQNT QPPSVASSLW DVTEVTERNN NGGAPPQQCS LVNNKKETRE
     EVKKNGTSLS SPFVLLDATK ELTMPKLPTV ELENPLLEPN GSCSNLSRKK EGEILVVAAS
     VLAGTIKDGC KGWLEKFSIG RSLIGRSNWR RRYFVLAPFN KGVSLSYFKD ESCHKPVALL
     LLNTNDTRIV TRPSVRTHKE ATQPEREICV IYVEKEKEYK LLLRAYSEDD REYWVYALSK
     LFDIINYPSD FPLLENAQE
//