ID   V5BHA8_TRYCR            Unreviewed;      1370 AA.
AC   V5BHA8;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN   ORFNames=TCDM_04172 {ECO:0000313|EMBL:ESS67109.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS67109.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS67109.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS67109.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR005719}.
CC   -!- SIMILARITY: Belongs to the SMC family. SMC4 subfamily.
CC       {ECO:0000256|ARBA:ARBA00006005}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS67109.1}.
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DR   EMBL; AYLP01000035; ESS67109.1; -; Genomic_DNA.
DR   EnsemblProtists; ESS67109; ESS67109; TCDM_04172.
DR   VEuPathDB; TriTrypDB:TCDM_04172; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   Gene3D; 1.20.1060.20; -; 1.
DR   Gene3D; 3.30.70.1620; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003395; RecF/RecN/SMC_N.
DR   InterPro; IPR024704; SMC.
DR   InterPro; IPR010935; SMC_hinge.
DR   InterPro; IPR036277; SMC_hinge_sf.
DR   PANTHER; PTHR18937:SF172; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR   PANTHER; PTHR18937; STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER; 1.
DR   Pfam; PF06470; SMC_hinge; 1.
DR   Pfam; PF02463; SMC_N; 1.
DR   PIRSF; PIRSF005719; SMC; 1.
DR   SMART; SM00968; SMC_hinge; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF75553; Smc hinge domain; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR005719};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT   DOMAIN          586..704
FT                   /note="SMC hinge"
FT                   /evidence="ECO:0000259|SMART:SM00968"
FT   REGION          363..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1031..1095
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          519..558
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          748..782
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          816..935
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1042..1059
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1060..1095
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1370 AA;  155433 MW;  98386EA08E4D00EF CRC64;
     MMCGAAGLCK LRVFFVVVVV LFLSTIFTDE ISSTFPCAFL TVMRVAGRGA VPASELTAGT
     RMVIRDIEVE NFKSYAGKHC IGPFHKTFTA VIGPNGSGKS NVIDAMLFVF GRNAKKIRLE
     RLSELIHSSA AHPNQAYASV TVHFVRLAET PENEGDPEYR QEVPESLLSI KREVYKSGSS
     QYFIDGVKTT QREVVEKLIA EGVDLEHNRF LILQGEVEQI ALMKPKSERE GEEGLLEYLD
     DLIGTNNFAE RISQASKAAE AAQQTRLEAL DRERKLRAER EALDDAKDSA IAFVTKDNHL
     QKTLIVMCQL RMQTLEEKLA EPRRLLTEID ERIASMKKTV ETHSKEKAKL DEDLLKRKRE
     LAEATKERDT VRRKKETADA EVERIKSGAD EQTKARKKAQ EQLKKAKEEL QKAELQQQDA
     DREVIIHQQN FEESTKRVEK LQKEYDSTTE ELAHVFVPLR QELEKTKAAF APYEEAVVEA
     TEQLDTARSR LASLDNGRLM TQEQLRKIDA ATERNGNRVA EIEELLQDAN KNRYKEELQR
     LQEMLAGAAE RKHSVNNAIQ EIKNAYREGE ADDRAMEFLL AQRSLKGYYG TLRQLGRIAD
     EYDIAAGVAS NAWGFHVVED RETAVAALEL LRKNNIGRAT MMVLKEIERE VGDRMNAPFT
     SPSPKATRLF DHIVPTNARF HVAFYQAVRD TLLVRDLGEA REVAFGGTQR ARVVTVRGEL
     AEPGGSITGG GNTPRGAKLK AARSPQDKEA ARVTLQRLQG ELVEAVEEER AAQEQLHKMR
     QTQRHLSSEQ ISKLRVELGT LRATLESDAK KRIALLQEME ENSAGSQSRR EAILEEVDEA
     EKSLQAANKS RLKHQSDLER IEQEMDAVGG AGYKALCAEL KLQQERREAE ENAIRECRRL
     SHRLHATQQR KQSDIAELEE ELKRINEEAA QGASGALAAA IATSEEWTRR YNGANAKFAK
     AQSDVEDVKT AVPVAHKALI EAQKLLDDEE RFRQVETAKM ADALQELAKF EQKIEGCEEK
     MRENAELYGI ETLQVDVNSG TDGDESTDEE EEKEVENEEY EEEERTKRSK KNKNRNNNRR
     AEEDEEELRR RPGKQQSNCI DLRNMSFRLS PEELARCDYE HSVRLAKTLS EETKRLHSEI
     DFRAVALWHE RDAEHRKGKS HYLSCKEASD AAERRLLELK EERRGRFMEC FVRVQERLRE
     VYQLLTHGGD ADLELVDAND PFEGIHFVVR PPKKSWKQIS NLSGGEKTLS SLALIFALHD
     IKPTPIYVMD EIDAALDFRN VSIVANYLLR QASGAQFIII SLRNNMFEMA HQLVGVCKVK
     DVTRTLALMP RGFQRMVEAE LLRLQRKRQA SDMVTFSNGD GENMQGCGRR
//