ID V5BJV8_TRYCR Unreviewed; 821 AA.
AC V5BJV8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Dual specificity protein phosphatase {ECO:0000313|EMBL:ESS64783.1};
GN ORFNames=TCDM_07067 {ECO:0000313|EMBL:ESS64783.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS64783.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS64783.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS64783.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class dual specificity subfamily.
CC {ECO:0000256|ARBA:ARBA00008601}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS64783.1}.
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DR EMBL; AYLP01000080; ESS64783.1; -; Genomic_DNA.
DR AlphaFoldDB; V5BJV8; -.
DR EnsemblProtists; ESS64783; ESS64783; TCDM_07067.
DR VEuPathDB; TriTrypDB:TCDM_07067; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14498; DSP; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR10159; DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR10159:SF538; SPECIFICITY PROTEIN PHOSPHATASE, PUTATIVE-RELATED; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT DOMAIN 561..748
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 666..700
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 88557 MW; 23A2592C2B8406BC CRC64;
MSLMPADGGE GVGPPREGNQ HQQQPPRPQQ QRCYNKQKNR EEEGENCEEE ETCPLEAFGN
APASNTSTDV SGAQGLTACK EEGSGDMTAT TTTRTAAVVK VVDTNAGSSQ QNGIVAPARS
GVTEYTCSGR SRSSSVGSSA HVSPSRFVVG STRHISLTTK PPAPGNGVRA SSVSLSSSQM
QAVIKFVSCR ASGDKKQNVT QASVPVGQSP LQTPGNDTSA STARASVDAT PMPTLSLSLQ
GQSSKGQMAS SSAIDLPLPH VSLRQCTSTP FVPNTVGTQP HSCYEKEEER DYFLQKVTPQ
LHRMLPLWRK NFGNEMVAEE GMKVTATTTT TEAKSESEAE CQQEQRQEKI LSENDIIDRR
LRQRLPEVSS RLHIRLPASP MCNAANSAYN PGSSDFDVSV SSSSSSSRTL STLQASSHHF
VRSVCHVLTG TPTFSSCNVG PEENETEKKF GISKAQTTNT STTTTTTTTK ATTMTIDGGG
GGGGSNSNSR SDGFVLTSHE QNDCICGVQA RGMDAPVEFV QENSTRQVLT KNGNRSGVFT
PSPLPPLPPL SHGACSSYSL DAAMVLPGLF LGSYSDALKI DALAAHGISL VINVAEECVM
METMIYNDYD IKFIKFPLKD HSDENITRYF GPITRIIHRQ LHRRERALRS SRKAATGNIR
IYDDDDEVMS ISNKSVGGGV LVHCRMGVSR SAAIILAYLM IYGETLWVDD NCSIQNQHME
EESLTPIFTP PNVSPISTLL LDGSDVEKEN HSTNGKCCEC CCCCLAIQTP HITCNTDGVY
TPSVVKSYRD AFEFLKKRKK DINPNIGFVL ALRELDNREG K
//
