ID V5BK56_TRYCR Unreviewed; 590 AA.
AC V5BK56;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Magnesium and cobalt transport protein {ECO:0000313|EMBL:ESS68149.1};
GN ORFNames=TCDM_03124 {ECO:0000313|EMBL:ESS68149.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS68149.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS68149.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS68149.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000256|ARBA:ARBA00009765}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS68149.1}.
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DR EMBL; AYLP01000023; ESS68149.1; -; Genomic_DNA.
DR AlphaFoldDB; V5BK56; -.
DR EnsemblProtists; ESS68149; ESS68149; TCDM_03124.
DR VEuPathDB; TriTrypDB:TCDM_03124; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015693; P:magnesium ion transport; IEA:UniProt.
DR CDD; cd12832; TmCorA-like_u3; 1.
DR Gene3D; 3.30.460.20; CorA soluble domain-like; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 2.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR PANTHER; PTHR46494; CORA FAMILY METAL ION TRANSPORTER (EUROFUNG); 1.
DR PANTHER; PTHR46494:SF1; CORA FAMILY METAL ION TRANSPORTER (EUROFUNG); 1.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 532..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 117..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 590 AA; 65563 MW; B4EBD81D9DA9E429 CRC64;
MLISSKVVWC RFLLNETLFH MSVRRGRVIR VVSPGWGNHP LYTTMASTYT ITEGSKVSLC
QPDWVSRTPA DNPGASPNFF SASSSSVNGG LAAPPRISPP GRRVSRWFFP GFTAEEAHRE
GVETSTDKTA VSSSRGEKRT LTSSASPKNT TVLPSLSTES RPMQPAGYNL ARRQEDKIER
THVVQGATKK APATNSPTPR GNAAPFSSTS LDDDLPSAFR DYQERRNQSI KAFLSTALGS
AFTKAGMDSD GLRTSFSAAA SEATKEAVGL RRISPKVLIS FLPGPDNAWN WVDISAHPTA
SLDEYRGALS QVLIDLGTHE TLVSDALEPM LLPQTTVMDG CHCLVVRYAE DVSKTRMDGF
QELTNRLTIL VKDTRVMTIH RTHCEFVENI KWNWLNLMKE HGMQGKTFLL NLLVKESVDT
FNTALTCCIV EFDNYEGSLF SSKRQRSTLA REMYHIKRRA SVYARVLVLT GEAYSQLCGA
LSIMPNDVQF QDVQQDIAHV RSLSEELHNN AESGLQLLFQ LSSFQLNELM RVLTIFSAFF
IPLSFVASIY GMNFEHLPLL EDEYGHMYCI AMMVAVGGGL GVWFKLRHFI
//
