ID V5BK66_TRYCR Unreviewed; 447 AA.
AC V5BK66;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Thiolase protein-like protein {ECO:0000313|EMBL:ESS66517.1};
GN ORFNames=TCDM_04889 {ECO:0000313|EMBL:ESS66517.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS66517.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS66517.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS66517.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS66517.1}.
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DR EMBL; AYLP01000044; ESS66517.1; -; Genomic_DNA.
DR AlphaFoldDB; V5BK66; -.
DR EnsemblProtists; ESS66517; ESS66517; TCDM_04889.
DR VEuPathDB; TriTrypDB:TCDM_04889; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR42689; ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED; 1.
DR PANTHER; PTHR42689:SF1; ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW Transferase {ECO:0000256|RuleBase:RU003557}.
FT DOMAIN 13..293
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 306..441
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 96
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 399
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 429
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 447 AA; 47935 MW; 2EBAB91C895580C4 CRC64;
MRCGRVLPKQ KAVFVTGART PFAKSFGSLM TVDNVRLGTA AVGGLLRKSK LDPKEVNHVI
WGNVVLQLDA HNCAREIVIE LNLPKNITAH FTSMACATGL NAMAQAVMMI ESGHADVVIA
GGSDSMSNAR LVAPATLSYG LARLTMGKKK GLAALPAFFK EAGYNPLSWL PRPLALEERS
TGRTMGWHGD LIGELNNISR ADQEALAIAS HKNASEAVMK GYMEEEVVPV TVTRNGETVE
FVKDEYIQSD IEKMKAKLPT LKPAFRRPNG TITPATSSGL TDGGSAMLLM SEEKAKQLGY
PTDISVKSWH FSAIDPYPQL LLAPVLGWGP TLKRAGLTAE DIDLFEIHEA FAAQVLATIK
CLQSPEFFER YTGSRDVVLK EKFDFSKLNV NGGAMALGHP FAATGGRLVT SLANELRRSG
KRHGLISICA AGGLGGIAVL EHTPGAN
//
