ID V5BPQ6_TRYCR Unreviewed; 334 AA.
AC V5BPQ6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Ubiquitin-like modifier-activating enzyme 5 {ECO:0000256|ARBA:ARBA00016279};
GN ORFNames=TCDM_03099 {ECO:0000313|EMBL:ESS68132.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS68132.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS68132.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS68132.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC subfamily. {ECO:0000256|ARBA:ARBA00005339}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS68132.1}.
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DR EMBL; AYLP01000023; ESS68132.1; -; Genomic_DNA.
DR AlphaFoldDB; V5BPQ6; -.
DR EnsemblProtists; ESS68132; ESS68132; TCDM_03099.
DR VEuPathDB; TriTrypDB:TCDM_03099; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR CDD; cd00757; ThiF_MoeB_HesA_family; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF9; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5; 1.
DR Pfam; PF00899; ThiF; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT DOMAIN 1..213
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
SQ SEQUENCE 334 AA; 36522 MW; 4AF1D6737E397AE6 CRC64;
MLTRCGISKI LIFDYDKVEL ANMNRLFYRP EQKGMTKVLA AKQTLEDINP DTEIVPYAFS
ITSTENWQDF VDALTKNGGV QPNSSVDLLL CCVDNFQARL TVNYACLLHN IPWMESGVAE
NAVSGHIQLL LPGVTPCYEC CPPLVVATGM PEAKREGVCA ASLPTTMGIV AGFMAQNTLK
YLLNFGTVSE YVGYDAMRDH FPSITIKANP ECRNETCVQR QQEYAARRAA MGDAAHPLHQ
ANKQREEREA KERAAARAKA TASAAEWGIV IEARGKEDLA VHAPQPEGVE AVSVEYAYSS
GAGNAAEHAQ EEFVMTDGGE SLEALMAKMK ALQH
//
