ID V5BQZ6_TRYCR Unreviewed; 705 AA.
AC V5BQZ6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 22-FEB-2023, entry version 31.
DE SubName: Full=Ribose-phosphate pyrophosphokinase {ECO:0000313|EMBL:ESS66988.1};
GN ORFNames=TCDM_04347 {ECO:0000313|EMBL:ESS66988.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS66988.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS66988.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS66988.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.
CC {ECO:0000256|ARBA:ARBA00006478}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS66988.1}.
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DR EMBL; AYLP01000037; ESS66988.1; -; Genomic_DNA.
DR AlphaFoldDB; V5BQZ6; -.
DR EnsemblProtists; ESS66988; ESS66988; TCDM_04347.
DR VEuPathDB; TriTrypDB:TCDM_04347; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:InterPro.
DR GO; GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06223; PRTases_typeI; 1.
DR CDD; cd14447; SPX; 1.
DR Gene3D; 3.40.50.2020; -; 4.
DR InterPro; IPR029099; Pribosyltran_N.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR005946; Rib-P_diPkinase.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR10210:SF111; PYROPHOSPHOKINASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR10210; RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER; 1.
DR Pfam; PF14572; Pribosyl_synth; 1.
DR Pfam; PF13793; Pribosyltran_N; 1.
DR SMART; SM01400; Pribosyltran_N; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:ESS66988.1};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW Transferase {ECO:0000313|EMBL:ESS66988.1}.
FT DOMAIN 11..188
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REGION 479..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 78893 MW; 2515FAB057252466 CRC64;
MRTGKGRSEG QAFHRRLLSE YNTEITLENY VAYFELKPIA KSVEQLRKEI DEHTSLAAAV
AAAAMLSSTS HEGTFDPMAT TESDPALEEM MKKRHELEEK FFVELRASFV KVKKYLWQLE
DDLLTRVHEL EQLTEEEIRA MPDECIAKLY VKVQTILRYR SLNLAAFRKI MKKFMERCAC
DSLELQQRLM SIDETIFNSA IAQPRLDLRR IALDLIALYG TVYRLTYEET VAHLSHYEYR
AGINIRRILP HSETFFFTLN FPHQERQGNF AARILSGSTS LFCEKMICEV LQCPRYPPCC
NQFPNGEINV SLSRTLRGDD VFVLQSLVRC DHLGLSHSGT FMELALMLHT ARLSSAARIT
AVIPYLAYAD SVSSVAVVAE LLEKMGCQHV ITVDMSSEQV EGMFSVPLEN ISARYEFVRF
IAKHLTNEGH DFRNITVVSP SGTSVSRAKY FADALMNYMK LSSAEQFVSV CTAVHRHPNL
PPPPPVKSVS HRPCATDKPT ATVTTTAASS ATCQTSVPEE KSSKQQEAHQ GYSHSRAGTV
LDLFSPPPRR ASPAHENASN TVAFVKALRQ QEEGVSAICE DRADNPAQTD GVALVGDVKG
RLCIIVDTTI DEAIKICRTA WKLHEAGASR IILIATHLIL SAGAEERLVK SPIDLIVVTD
SVNQDVVFKK PLFAQKLRLL PIAPLLARAI EKMHTENTLA TLFEK
//
