ID V5BR43_TRYCR Unreviewed; 1114 AA.
AC V5BR43;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Helicase-like protein {ECO:0000313|EMBL:ESS70329.1};
GN ORFNames=TCDM_00780 {ECO:0000313|EMBL:ESS70329.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS70329.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS70329.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS70329.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS70329.1}.
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DR EMBL; AYLP01000005; ESS70329.1; -; Genomic_DNA.
DR AlphaFoldDB; V5BR43; -.
DR EnsemblProtists; ESS70329; ESS70329; TCDM_00780.
DR VEuPathDB; TriTrypDB:TCDM_00780; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18007; DEXHc_ATRX-like; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR044574; ARIP4-like.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45797:SF1; HELICASE ARIP4; 1.
DR PANTHER; PTHR45797; RAD54-LIKE; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Helicase {ECO:0000313|EMBL:ESS70329.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 312..496
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 692..855
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 163..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1013..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1038
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1114 AA; 126368 MW; 2FDD6D81F23060D5 CRC64;
MLYRRTREEL LCGSLPFPFF GVMHRCFIYR KCFSFPFFFL YCFGPSAFYC CCCFRRRATV
RRMDGPELFV ISTSESEDGD GTDGANVADV SALAEDARSN LSFRHCGVEN MFIDEVLFGD
RDRRSVLLPD TGARATDADS LSSSSSDSDR SLFAQELVGE ETKRLSQGPG VVEDKGTLDP
HEPLTSTAVL RSMTCADVRA VLEPFFRRKE AAKARFDAVQ KWLAEEMAAK TTRMKKSMLE
RWRRLVNISN WGDGSSSRDD ILFPEALVPP AATLLGVLGP SVAKNVLPEL QHLRPHQIDG
IRFLWSILAE GPVGRVPAVG CILAHTMGLG KTCQVVIFLH LLLNEKRGCL GRSQRVLIVV
PKSTRPGWQK EFSTWSQYFP LAHRILPIMI DERDGMKRRL DLYRSWWSEG GVLLVGYEML
LGLTKLSKEG SREDKKGCEF TDLLICDEAH RLKSTRLQIS AALRGLHPLR RLLLTGTPLQ
NHLQEYWAMV DFAVHKYFEK RRFQEFFINP IEASVAQEAS SRVVATARMK TFALIRELRH
FVQRVDSTPL RDELPPLHEY VLVIPLSALQ VRLYNRFLHL ARLEQSKFNF LQAVTYANKI
SAHPQLLFDS DPASPLKEIL SEVESSPDDD DNNNNNNNVG DNMGKGNRRH GDRRRTAFSG
PVNEGYAELF QPPVDYTAAP EDGVKLYIAI RIIKAAMLRG ERALFFSLST KMLSLFEGII
AEMNRRWQQD GSLPRPIRFC RLDGNSSGAE RENTLRSFNS LRGADVLLLS MKAGGVGINI
TSATRVILAD SGFNPADDRQ AIGRAYRYGQ TRPVFVYRLV CYQTLEHRMF QQKVAKEWLF
HTIVEEASLK RDALTGLRLQ SMIQLLGRSL EVSSEVPALT DEQRDSTARL FTEDAVLAEL
ADSIIYVESH EVYLQHDELV QYGKEEREFY EEYQKKGVFN IDSYMDGVNV GNETEQRKRQ
REKHQEDIGR QTKTLTALVD DVIRGRAEQD PRLRHLLRMM GITVDASGVV SVSSMQETQR
RTREPIAVDG EDGSNSSDDR LIRRLQGEKL ARTETASPLR PIVLNQSDDD DEDSILFEGK
KKKHVALVID PSIYEPYKPG RNAYNAIFID EDEV
//
