ID V5BRP6_9GAMM Unreviewed; 530 AA.
AC V5BRP6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=MGMO_170c00060 {ECO:0000313|EMBL:ESS67238.1};
OS Methyloglobulus morosus KoM1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methyloglobulus.
OX NCBI_TaxID=1116472 {ECO:0000313|EMBL:ESS67238.1, ECO:0000313|Proteomes:UP000017842};
RN [1] {ECO:0000313|EMBL:ESS67238.1, ECO:0000313|Proteomes:UP000017842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KoM1 {ECO:0000313|EMBL:ESS67238.1,
RC ECO:0000313|Proteomes:UP000017842};
RX PubMed=24356841;
RA Poehlein A., Deutzmann J.S., Daniel R., Simeonova D.D.;
RT "Draft Genome Sequence of the Methanotrophic Gammaproteobacterium
RT Methyloglobulus morosus DSM 22980 Strain KoM1.";
RL Genome Announc. 1:e01078-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS67238.1}.
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DR EMBL; AYLO01000155; ESS67238.1; -; Genomic_DNA.
DR RefSeq; WP_023496428.1; NZ_AYLO01000155.1.
DR AlphaFoldDB; V5BRP6; -.
DR STRING; 1116472.MGMO_170c00060; -.
DR REBASE; 76763; M.Mmo22980ORF40P.
DR PATRIC; fig|1116472.3.peg.3823; -.
DR eggNOG; COG0286; Bacteria.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000017842; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:ESS67238.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000017842};
KW Transferase {ECO:0000313|EMBL:ESS67238.1}.
FT DOMAIN 12..142
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 155..492
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 530 AA; 58833 MW; C6BBE5D09521CDA2 CRC64;
MAKAKTANEE PLEKQLWKAA DKLRKNIDAA EYKHIVQGLI FLKYISDSFE EHFAKLQAGE
GDYAGADPED KDEYSAENIF FVPSEARWSF LQAQAKQPNI GTLVDEAMDA IEKENTSLKG
VLPKVFARQN LDPTSLGGLI DLVGNIALGD AKARSADVLG HVFEYFLGEF ALAEGKQGGQ
FYTPRSIVEL LVNMLEPYSG RVFDPCCGSG GMFVQSEKFV EEHQGRVNDI SIYGQESNQT
TWRLAKMNLA IRGIASDQVK WNNEGSFLND AHKDLKADYI IANPPFNDSD WSGDQLRSDG
RWQYGTPPAG NANFAWLQHF AYHLAPTGQA GVVLSKGALT SKTSGEGDIR KALIEDGNLI
DCIVNLPAKL FLNTQIPAAL WFMSRNRNNG KFRNRSGEIL FIDARNLGHL INRRTRELSP
DDIKQIADTY HNWRNPDSDA QGRANVAGGG KPGATTYEDI KGFCCSASIE RVKELDYVLT
PGRYVGLPDE EDDFNFAERF TALKTEFEAQ LLEEAELNKA IADNLAKVKL
//
