ID V5C5Y4_9GAMM Unreviewed; 756 AA.
AC V5C5Y4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Competence protein ComA {ECO:0000313|EMBL:ESS73872.1};
GN Name=comA {ECO:0000313|EMBL:ESS73872.1};
GN ORFNames=MGMO_8c00090 {ECO:0000313|EMBL:ESS73872.1};
OS Methyloglobulus morosus KoM1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methyloglobulus.
OX NCBI_TaxID=1116472 {ECO:0000313|EMBL:ESS73872.1, ECO:0000313|Proteomes:UP000017842};
RN [1] {ECO:0000313|EMBL:ESS73872.1, ECO:0000313|Proteomes:UP000017842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KoM1 {ECO:0000313|EMBL:ESS73872.1,
RC ECO:0000313|Proteomes:UP000017842};
RX PubMed=24356841;
RA Poehlein A., Deutzmann J.S., Daniel R., Simeonova D.D.;
RT "Draft Genome Sequence of the Methanotrophic Gammaproteobacterium
RT Methyloglobulus morosus DSM 22980 Strain KoM1.";
RL Genome Announc. 1:e01078-13(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS73872.1}.
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DR EMBL; AYLO01000008; ESS73872.1; -; Genomic_DNA.
DR RefSeq; WP_023493107.1; NZ_AYLO01000008.1.
DR AlphaFoldDB; V5C5Y4; -.
DR STRING; 1116472.MGMO_8c00090; -.
DR PATRIC; fig|1116472.3.peg.185; -.
DR eggNOG; COG0658; Bacteria.
DR eggNOG; COG2333; Bacteria.
DR OrthoDB; 9761531at2; -.
DR Proteomes; UP000017842; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017842};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 511..698
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 756 AA; 82512 MW; 1A99A09498F6AACE CRC64;
MVVFVLCFLV GILCVQQMTA LPEPIWAVAV VCAAAVTVWL RCWGGLFLLL GILWAAVFAS
LSLNHRLPEQ LAGQDIQIQG YIADLPEHEG NHVRFNFTVT GSTKQIPPKL RLTWYYPDKV
VKAGQEWAVT VRLKPPHGTF NPGGFDYERW LFLEGIGASG YIRPKPEPRL VDSGSTKTSL
LVWRQHIAEQ LARTLANSES LPLIKALTIG DGNSLSPRQW EIFRQTGTTH LMVISGSHIG
LIAGLVYLLV VRFWAWTGIL VWSPQKVAAM TAMVVAIFYA GLTGFSVPAQ RSALMIAIAM
TAIVQQRNTR PFNVLAVALF AVLVIDPLVV LSAGFWLSFI AVSLIIYVIA GRLGKPGLIR
GSIKINWVTS IGLAPLLLFF FQQVSLISPL ANLIAVPIIS LLVVPIALFA TLILFVAPIV
AAKLFIVVDV TLQGLWWVLV KLAALPLSTA AHSQPSGWAL VFAIPGILLL FSPKGMPSRH
LGWVMLFPLV FTGSSIIHPG AVKLTLLDVG QGLSAVVQTA NHVLVYDAGA KFSATSDMGQ
SVVIPFLRYQ GIDKVNTLIV SHGDNDHIGG VGSVVGHIDT GDILTSVPLQ LMEYSPIQCK
VGQSWTWDQV TFSILSPKVA NLLSDNNNSC VLQIQAQKGT ALLTGDIEAE AESWLVETYK
DKLKADVLIA PHHGSQTSST STFLKAVQPN TVLIPVGYRN QFGHPHQDVL RRYSDLHIRV
FNNSEDGSIE VNMDNGIKVE AWRATEARYW NNVVSR
//
