ID   V5CZ38_TRYCR            Unreviewed;       927 AA.
AC   V5CZ38;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS60496.1};
GN   ORFNames=TCDM_11975 {ECO:0000313|EMBL:ESS60496.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS60496.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS60496.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS60496.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS60496.1}.
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DR   EMBL; AYLP01000459; ESS60496.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5CZ38; -.
DR   EnsemblProtists; ESS60496; ESS60496; TCDM_11975.
DR   VEuPathDB; TriTrypDB:TCDM_11975; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   InterPro; IPR021287; Trans-sialidase_CS.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF11052; Tr-sialidase_C; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        43..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          93..439
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
FT   REGION          13..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          721..832
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          853..878
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..37
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        768..789
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        798..812
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   927 AA;  98359 MW;  56120EF050C16731 CRC64;
     MLSRVAAVMA PRTHNRRRVT GSSGRRREGG ESERQRPNMS RRVFASAILL LLVVMIFCST
     GAALAEVKQS SETKYQWKGI SEGEDVTVKL FGIPGLLKVG SDVFAVAEAQ CKKKDKEDTF
     TGIASQLLTI KDDNTPEKAL KNARVIRVLE EGVSTEVKIV EVSRPTAVVD GGDIYMLVGK
     YSGNAGARKS GAAQSGILLV KGTVSGEESN KQIDWKDTNA VPKTAFGEHD SSMQLIGSGG
     SGVKLKDGTL VFPVEGTKKK DKTEEDEKTK TVSLVLYLQD TKSWTLSKGM SADGCSDPSV
     VEWEKDKLMM MTACDDGRRR VYESGDKGNT WTEALGTLSR VWSNKHEGSE KGVGSGFTTA
     TIDGDDDKNV MLVTLPVYAK DNNIVKGELH LWLTDNTHIV DIGPVSEKDD DAAASALLYK
     SGKSGTDEEK KEELVALYEE KKGSGESSNS LWSVRLTEQL QRVKDVLATW KKVDEHVSGL
     CPSESAAKGP SPESACKNTK ITAGLVGFLS GNFSDDTWKD EYLGVNATVK GTKEGVPAET
     AESSDGVKFR GAWAEWPVGE QGENQLYHFA NYNFTLVATV SIDGEPKEGD TSIPVVGAKM
     NGDDKNPVLL GLSYNKKEKK WILLCGGKPT EVQKRIEGQE KTQQVTIVLQ NGNHSTAYVD
     GQRVGDVQCQ LEGKEDKKIS HFYIGGDGSN TGSRDGVSVT VSNVLLYNRP LDDSEITALD
     TIKPPITPPK DPNAQKIVVP SFGGTPHAGQ EPLNGGEGAD GLGVPEAASI ASTSSGSGQT
     VQQLASETPP DGNADEDGAP SSSGNPTVGE GSADTIQGDG RHTPSVGDTP ATADTNVLTA
     ETVGHDGAAL TTEVTVSSGA DGETTGGTDG QEEEEIHPQD RDLNATALSS SLGNLSQGTN
     TDAGTVSGRR VLPLLLLLLG LWGFAAL
//