ID   V5D4R1_TRYCR            Unreviewed;       793 AA.
AC   V5D4R1;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Choline/carnitine O-acyltransferase {ECO:0000313|EMBL:ESS62471.1};
GN   ORFNames=TCDM_09869 {ECO:0000313|EMBL:ESS62471.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS62471.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS62471.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS62471.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS62471.1}.
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DR   EMBL; AYLP01000182; ESS62471.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5D4R1; -.
DR   EnsemblProtists; ESS62471; ESS62471; TCDM_09869.
DR   VEuPathDB; TriTrypDB:TCDM_09869; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589:SF31; CARNITINE O-PALMITOYLTRANSFERASE; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000313|EMBL:ESS62471.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ESS62471.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        64..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          195..781
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        488
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   793 AA;  91407 MW;  7F8999D8B85CEDFE CRC64;
     MAEARFAVRP TAALHHVGFE VDTSRKQTQL YVSRRGLVLY VPHPYFIIKN MRRSFWHGVD
     KVQFALYPIP LSVVTAFSFG VFLWVLNSPA DAWIRVNCVS DILWRLDERN FISSRIPSRY
     RMPALCANVA FGAVTLFTAL QRFVLRKLLS YNRWIYEGQG KLTRKTMLWG FILKTFFMHN
     LKRTGAYGSC LPSQPLPDLK ITVQRFMKSM VPFYEEKTAE WEHLKKLSED FLRNEGPQLQ
     RYLWLKYLLA DNYMTDWWIK YVYLAQRESL CINSNWFGVA FAKYLPTPLQ ASRAAALVYN
     LIKVKKSLDR RTFPPQFSGL VPLDMNQYRY VFNTTRIPGR EMDVLAQHEG IKHIVVIHKG
     RFYQLEVLHP LTNHQLTPYQ LEMALESILH SEDETDPVEA LIPAFTTAPR AEWADIRDKH
     FVNNAYNVKP LRVIEEAIFV LCLDEMEPKS LEEESMMYLC GNGHNRWCDK SFNVIVTEGG
     HCGVHAEHSW GDALTLANVV EYSHASDEFK ELYTEDGHVK KLPEDEVALA EGKFKVFVPN
     RIRFTTDAVM KRAVQGAQER CIREIKDVDI RVCRFADYGK GFPKKQRCSP DAWVQMAMQL
     AYFRDQGHFD QTYEAASMRM YRKGRTETIR TVSEESCAFV RAMEQPSLSA EAKLKLLRVA
     CERHQKTSRD AIAGCGIDRH LFGLYCASTG FEVASEFLQA AMQSKWKLST SQVLTRQLPA
     KFHPPNDEPF ETPNGGFGPV QDDGYGVCYC LYGENLFYFT ITSKHSCKST SSTRLAEHIK
     KALRDMAALT GWN
//