UniProt: V5D9Y6

Database: UniProt
Entry: V5D9Y6_TRYCR

LinkDB:  V5D9Y6_TRYCR 
Original site:  V5D9Y6_TRYCR

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Ontology (2)   
   GO (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (8)   
   InterPro (3)   
   Pfam (2)   
   PROSITE (3)   
Literature (1)   
   PubMed (1)   
All databases (13)   

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ID   V5D9Y6_TRYCR            Unreviewed;       673 AA.
AC   V5D9Y6;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE            EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN   ORFNames=TCDM_07707 {ECO:0000313|EMBL:ESS64266.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS64266.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS64266.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS64266.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS64266.1}.
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DR   EMBL; AYLP01000095; ESS64266.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5D9Y6; -.
DR   EnsemblProtists; ESS64266; ESS64266; TCDM_07707.
DR   VEuPathDB; TriTrypDB:TCDM_07707; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF01529; DHHC; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50216; DHHC; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU079119};
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Membrane {ECO:0000256|RuleBase:RU079119};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW   Transferase {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM        210..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        284..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        381..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        423..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   REPEAT          74..106
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          341..458
FT                   /note="Palmitoyltransferase DHHC"
FT                   /evidence="ECO:0000259|Pfam:PF01529"
FT   REGION          532..551
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   673 AA;  74425 MW;  2D442004002BCD35 CRC64;
     MVCRQGRGAE FAALFLIEQL GVDVNAREGE TAATTGVHDG DHHYRPIEAN TATTAAAAIQ
     RCDSAPHSGV IVKEGLTPLH CAVLVGDTLL LRSLLLKGAD VEKPDATGRT PIQLAKDCAM
     SSSPSLLTSL LSFIRFQCSF LGLTQRNGRT AKNIDPWKVY TILDAHCKEA SSAKREANLQ
     REAAADTSLW RLNTISDILS FGAAAALPHF LMALCALMGM PLWILIVFAT IELILCNGFK
     VEDERRLNVR PLRCVGFLVG YTLVLLACSI SLEDAMEPRR MNTRPWLFLC TIGSALCAFL
     VMWMNPGIVE STAGQRVGIY KTIFYSKGAP PEDVRQGIDL SCMVKKPLRA QRCRHLGRVV
     LRYDHYCTWL ASAIGGGNHR LYIAFLLFYT VLLGICCRGT YWLSPNQMNN EMFFDDLHFR
     RFANVYILFV LPVAFIFSLY TLLQQLWYIA RGVTAYDVAQ PSCCPWCFQL GSRTYSLFDA
     GFWRNVCGFF FLREKFLNIS YRMPVMSVRL QKMAKRHQAL QLSSCHDGHC HSHENGGHGH
     SHNGHLGQLH QYNPQQRSNA PLNTALSNVA EGIDSPATTA VVINSSTPAS ALASDPFPSV
     AVDTTAAATQ LGFEASVGRL FQLMVQHGDT DLTAVAAANE IRASVLPEKW QEIVEMAQSM
     YGFFKSTMNN ANN
//

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