ID V5DUN9_TRYCR Unreviewed; 744 AA.
AC V5DUN9;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=DNA repair protein RAD2 {ECO:0000313|EMBL:ESS71101.1};
GN ORFNames=TCDM_00128 {ECO:0000313|EMBL:ESS71101.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS71101.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS71101.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS71101.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
CC {ECO:0000256|ARBA:ARBA00005283}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS71101.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYLP01000001; ESS71101.1; -; Genomic_DNA.
DR AlphaFoldDB; V5DUN9; -.
DR EnsemblProtists; ESS71101; ESS71101; TCDM_00128.
DR VEuPathDB; TriTrypDB:TCDM_00128; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:UniProt.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR001044; XPG/Rad2_eukaryotes.
DR InterPro; IPR019974; XPG_CS.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081:SF54; FI23547P1; 1.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR PRINTS; PR00066; XRODRMPGMNTG.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00841; XPG_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT DOMAIN 1..96
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 467..532
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 128..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 744 AA; 82700 MW; ACEC91347583ECEF CRC64;
MGVHGLWRLL DTFGEVTQPS DWRGKRVAID ASIWMSQFRA KCTSGENMEQ CILEGFFLRI
LKLLFYGIEP VFVFDGTATD LKSTERRRRA ERRAALERSA LTRRAQQIVK AQLASGLLNV
QALDQKVPVK TAGRPPSPKK ETDAGMLQSS SLTNISDTAT GCCSTNPRSL LRKRRREIVL
EPDAISRTLT DSFLTEAEEW IEERKRGEMC VEANLLFYSS TSLFMGPRGV LEDKINAPIK
AAVLPEKDTN PPAYMSLSSL SSEEASLVIS DDDKTSINDY ETVSTGITSS RGSVVIVGGH
PETFPDRLRE MEEITIHSLH DDSCDTWLEK DMATCDDILS FCNEGDSSGG SGHSNSDHDD
SVQPWNPGTQ LICQSSTETT RKHREVSDDG IERPKAASIG SVEETTREGS SSPVTKNLMG
AVDVTRSLET PSPSHPPQTL LPKPITKGAK AHQVIPFELL EILELLDCCG IPFVLSPHEA
DAQCAFLSQQ RLVDAVFSED SDVIVHGANV VLRGFFSKNR YVVVYRQSDL AMCGVDKDVL
VALALLLGCD YAEGVDGVSL LEALRIITAF WHQESVQGPS HVLDMLTRWR DAVAQRRFVW
EEEGVLLQSY LNWRRWSTLR VAADFPQVPV VDAFFSATVD ADMRPFAVAS PEWNRLRTFA
GMHGLLGDVT CQQRLELAQK AFLARELQRN NERKQQQLRL TDFAMPSHAK EKVAYKKQSP
KFAAALSALR AARRSGVRVD CCHY
//
