ID V5ENF8_KALBG Unreviewed; 1138 AA.
AC V5ENF8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DUF221-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PSEUBRA_SCAF9g01255 {ECO:0000313|EMBL:EST04468.1};
OS Kalmanozyma brasiliensis (strain GHG001) (Yeast) (Pseudozyma brasiliensis).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Kalmanozyma.
OX NCBI_TaxID=1365824 {ECO:0000313|EMBL:EST04468.1, ECO:0000313|Proteomes:UP000019377};
RN [1] {ECO:0000313|Proteomes:UP000019377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GHG001 {ECO:0000313|Proteomes:UP000019377};
RX PubMed=24356824; DOI=10.1128/genomea.00920-13;
RA Oliveira J.V.D.C., dos Santos R.A.C., Borges T.A., Riano-Pachon D.M.,
RA Goldman G.H.;
RT "Draft genome sequence of Pseudozyma brasiliensis sp. nov. strain GHG001, a
RT high producer of endo-1,4-xylanase isolated from an insect pest of
RT sugarcane.";
RL Genome Announc. 1:E0092013-E0092013(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; KI545895; EST04468.1; -; Genomic_DNA.
DR RefSeq; XP_016289457.1; XM_016439559.1.
DR AlphaFoldDB; V5ENF8; -.
DR STRING; 1365824.V5ENF8; -.
DR GeneID; 27422276; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_009187_0_0_1; -.
DR OMA; GKGFFAW; -.
DR OrthoDB; 1330110at2759; -.
DR Proteomes; UP000019377; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019377};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 40..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..703
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..191
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 215..379
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 391..674
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 987..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1030
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1059
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1138 AA; 125707 MW; ED181CB53250E290 CRC64;
MSQTATFPSL VARQNNGNGV VPSALIEQLN ANGATDLKKV GITIVAFVAL ALVTVIAFQI
LRPNNKIVYA PKYKYAEEGK APPKASEGFF GWLPPIIKYK EHDLLPLIGL DGVTFLRFIR
MMRWMLTTLA ILMSVVLMPV DIAYNMRNGG SNLVTNKLNY LNMSNVHGNY MWAHVGMSYV
GTIVALAFIW YHYREMVRLR WAYFRSEEYQ TSFHARTLMI TDVTKRYQAD NALGAVLSEL
KMPYPTTEVH IGRRVGILPD LIEKHNDLVR ELERVLAKYL KNPNQVPAKR PTKTIGGFMG
CGGKKVDAID YLTSQINRVE AAVMHQRDTI QDKQPEMYGF ASLAAVPYAH AAAKVLQGKR
PGGMRVTLAP PPTGIIWKNL TRSRASRAKS SFFGFLMLLV LFFLNIFPLI IVSLLSNMAG
LTTISWLGWL KDWQSSSSFT FAAVSGLGAP IIMGIASFFF PLAMRRIAKY RGIQTRYRLD
RLLVGQYFGF LVISQFLFFS LIGVILSLVS QLVVEINKDS ALNIIERLGR TAAYAAKQQY
LNQSNYWLTW LPLRGYLAVF DLAQVIKLML VWVQKVFFGR TPRDVREYTK PPVFDYWMYY
ANFLFMAAVA MIYAPLAPLV IVFSAVVFWA NSFIYKYQLM YVFVTKHETG GMLWRPAINR
LLVCIGFMQV ILILAVVLDT LNYYQAIAAL PPILMLVGFK IYCRTTFDRR FDWYIPNEAE
IAASKIHGGD ARHNRLQRRF GHPTLHSKLF TPMVHAKVKH LLPQVYKGRI DQGVAVVDGR
KVETEQVAGG LKIAAIEEDQ LEYDPRKDSD NRSVMSGTTL GGMSMAGIGA TSPDDLAETR
ANYFKDQYAN YMAGGNTHGG EEFEMANVSA RDSRDNLLEK RQHSLYNESL DGTLAGTTYG
GKSSPEGVGA HGAYNSYSAN TTPAFEGGMP QQARYVDPYA QIGQSQLPRM GANHSAQGSQ
TSLGSYGNLL YGSTNPAVAA ATAAAATPAR GYGPPASQAP SYGGSTMGRT PSPGQPQQIS
PGTVIAPMAT STPQYHAGGG GGYTASPPNY QQPQRFMGAP PSRQASADYP YHPSGGYGQQ
QQSPQHAPVY AHQQQAASQP GQPYAHGQQS SGGNYYPSQH GSHGGSGYQQ GGPHGYQR
//
