ID V5ERZ8_KALBG Unreviewed; 355 AA.
AC V5ERZ8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Glyoxylate/hydroxypyruvate reductase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PSEUBRA_SCAF9g01390 {ECO:0000313|EMBL:EST04639.1};
OS Kalmanozyma brasiliensis (strain GHG001) (Yeast) (Pseudozyma brasiliensis).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Kalmanozyma.
OX NCBI_TaxID=1365824 {ECO:0000313|EMBL:EST04639.1, ECO:0000313|Proteomes:UP000019377};
RN [1] {ECO:0000313|Proteomes:UP000019377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GHG001 {ECO:0000313|Proteomes:UP000019377};
RX PubMed=24356824; DOI=10.1128/genomea.00920-13;
RA Oliveira J.V.D.C., dos Santos R.A.C., Borges T.A., Riano-Pachon D.M.,
RA Goldman G.H.;
RT "Draft genome sequence of Pseudozyma brasiliensis sp. nov. strain GHG001, a
RT high producer of endo-1,4-xylanase isolated from an insect pest of
RT sugarcane.";
RL Genome Announc. 1:E0092013-E0092013(2013).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; KI545895; EST04639.1; -; Genomic_DNA.
DR RefSeq; XP_016289628.1; XM_016439694.1.
DR AlphaFoldDB; V5ERZ8; -.
DR STRING; 1365824.V5ERZ8; -.
DR GeneID; 27422411; -.
DR eggNOG; KOG0069; Eukaryota.
DR HOGENOM; CLU_019796_1_2_1; -.
DR OMA; GHTPKHW; -.
DR OrthoDB; 1462550at2759; -.
DR Proteomes; UP000019377; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR10996:SF257; GLYCERATE DEHYDROGENASE HPR, PEROXISOMAL; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000019377}.
FT DOMAIN 6..339
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 117..317
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 355 AA; 38372 MW; 61915BA7E0432478 CRC64;
MTVPKILVCR RMPTEVLKRA EAAGKVELIT QPESDGERAP SRSWVLSNLP GCAGAVICLS
EKVDASFLDA AGPSLKVIST MSVGYDHIDL PLVKSRGICV GNTPRVLDDA VAEVCLLLAL
MVTRQVPVAT RTVREGEWPN FPWTPTCFMG PSIAGKTVGL LGFGNISQSL CKLLVPFKPK
RILYTTSRER KFDREDKYFA SLMRDGFPVD RIGVENEPEP IELAKKADLV FVLVDLNAST
KHIVGKKFLE AMKPSAYIIN ASRGGTVDTA ALVEALRNNQ IAGAGLDVVE GEPGIHADHP
LLSADVRDKV ALLPHIGSGT TETRQAMADM TMNNLLGALG LREEQGKEAE MDAEL
//
