ID   V5EYK0_KALBG            Unreviewed;       838 AA.
AC   V5EYK0;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Smr domain-containing protein {ECO:0000259|PROSITE:PS50828};
GN   ORFNames=PSEUBRA_SCAF14g01635 {ECO:0000313|EMBL:EST08848.1};
OS   Kalmanozyma brasiliensis (strain GHG001) (Yeast) (Pseudozyma brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Kalmanozyma.
OX   NCBI_TaxID=1365824 {ECO:0000313|EMBL:EST08848.1, ECO:0000313|Proteomes:UP000019377};
RN   [1] {ECO:0000313|Proteomes:UP000019377}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GHG001 {ECO:0000313|Proteomes:UP000019377};
RX   PubMed=24356824; DOI=10.1128/genomea.00920-13;
RA   Oliveira J.V.D.C., dos Santos R.A.C., Borges T.A., Riano-Pachon D.M.,
RA   Goldman G.H.;
RT   "Draft genome sequence of Pseudozyma brasiliensis sp. nov. strain GHG001, a
RT   high producer of endo-1,4-xylanase isolated from an insect pest of
RT   sugarcane.";
RL   Genome Announc. 1:E0092013-E0092013(2013).
CC   -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC       {ECO:0000256|ARBA:ARBA00009375}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KI545856; EST08848.1; -; Genomic_DNA.
DR   RefSeq; XP_016293837.1; XM_016434821.1.
DR   AlphaFoldDB; V5EYK0; -.
DR   STRING; 1365824.V5EYK0; -.
DR   GeneID; 27417428; -.
DR   eggNOG; KOG2554; Eukaryota.
DR   HOGENOM; CLU_014673_2_2_1; -.
DR   OMA; YEMAADR; -.
DR   OrthoDB; 167554at2759; -.
DR   Proteomes; UP000019377; Unassembled WGS sequence.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.110; -; 1.
DR   Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR   Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR001406; PsdUridine_synth_TruA.
DR   InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR   InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR   InterPro; IPR002625; Smr_dom.
DR   InterPro; IPR036063; Smr_dom_sf.
DR   InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR   PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR   PANTHER; PTHR11142:SF5; TRNA PSEUDOURIDINE(38_39) SYNTHASE; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR   SUPFAM; SSF160443; SMR domain-like; 1.
DR   PROSITE; PS50828; SMR; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019377};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   DOMAIN          44..122
FT                   /note="Smr"
FT                   /evidence="ECO:0000259|PROSITE:PS50828"
FT   REGION          212..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          757..838
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..245
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        793..824
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   838 AA;  91535 MW;  AA14FC646AF6FCD3 CRC64;
     MRGKLVGNGL GICLGVVRPG ALQGSQASSA TANLSVDERT ECLLDLHGLH AKEAVEMTEQ
     FLLGLEAEGI QGLAYLAIGK AKHSSKETDK RRVKVGGFIK QFLSSYSYPF AESDGVLVVD
     HLTHSRPHTL PASIPGAVCM AHARLSLRLI ERTQAATAAL RSLHTSRICA RADTPQRIWQ
     RKMEAKERYR DWTKEALLSR IADLEAQATS TRAAQARIDT DAHVARSGPS ASSSAEPQGE
     NGQVTTKKKG AGKKEKKPKE FDFASSPCRK IALRFSYDGA GYSGLAAQNA TEAGSGSSMP
     TVEGVLWDAM CTARLVDPAI GMDGAGFSRC GRTDRGVSAA GQVVALWVRS KKVNQWQERL
     DHQEQFSTDP AQHTAEEWEQ LQAKRSAKLE EVELPYVQIL NRILPASIRI QAWSPVRSNF
     SSRFDCVYRH YKYFFPAGPP GVFYTPSSAN TGASAGSGQD AGATRLDINL MRDAARRLLG
     EHDFRNLCKI DASKQITNYR RRIDGVSIDR VSSHWPSSSV AVTDSGMEEG QEAMYVLNLR
     GTAFLYHQVR NIMAILFLVG ARLEAPSVVE ELMNTQKGQI AADRVKMRLA AQKTTRSTAS
     EGDRDDIKWW LPVNATSSST ESTPEGLPMW MHTALSSDPV EHAAADEGLE VYETKPNYEM
     AADRPLVLWE CGFLPSDVEW RVGPYDGALS SIPASDAGEN LGTASASLLR MHKTWTQHAI
     STELSRHFVL AAPSPHVGTL PSRTAFEEAS FPCLPSATAA EHERSEEGKD GGGKAGVIPL
     GNGTGRGAAN YVPMKHRPRE ETYEVKNRRW AETTGKRRAE RKSQQQQGAG ETMQVDDE
//