ID   V5FBV8_BYSSN            Unreviewed;       755 AA.
AC   V5FBV8;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Carotenoid cleavage dioxygenase {ECO:0000313|EMBL:GAD94264.1};
GN   ORFNames=PVAR5_2888 {ECO:0000313|EMBL:GAD94264.1};
OS   Byssochlamys spectabilis (strain No. 5 / NBRC 109023) (Paecilomyces
OS   variotii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX   NCBI_TaxID=1356009 {ECO:0000313|EMBL:GAD94264.1, ECO:0000313|Proteomes:UP000018001};
RN   [1] {ECO:0000313|Proteomes:UP000018001}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=No. 5 / NBRC 109023 {ECO:0000313|Proteomes:UP000018001};
RX   PubMed=24407650; DOI=10.1128/genomeA.01162-13;
RA   Oka T., Ekino K., Fukuda K., Nomura Y.;
RT   "Draft genome sequence of the formaldehyde-resistant fungus Byssochlamys
RT   spectabilis No. 5 (anamorph Paecilomyces variotii No. 5) (NBRC109023).";
RL   Genome Announc. 2:E0116213-E0116213(2014).
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC       Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC   -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC       {ECO:0000256|ARBA:ARBA00006787}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAD94264.1}.
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DR   EMBL; BAUL01000085; GAD94264.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5FBV8; -.
DR   eggNOG; KOG1285; Eukaryota.
DR   HOGENOM; CLU_016472_5_0_1; -.
DR   InParanoid; V5FBV8; -.
DR   OrthoDB; 294919at2759; -.
DR   Proteomes; UP000018001; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   InterPro; IPR004294; Carotenoid_Oase.
DR   PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR   PANTHER; PTHR10543:SF24; CAROTENOID ISOMEROOXYGENASE; 1.
DR   Pfam; PF03055; RPE65; 1.
PE   3: Inferred from homology;
KW   Dioxygenase {ECO:0000313|EMBL:GAD94264.1};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR604294-1};
KW   Oxidoreductase {ECO:0000313|EMBL:GAD94264.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018001}.
FT   BINDING         403
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         452
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         526
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         733
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ   SEQUENCE   755 AA;  84215 MW;  ECB172C9B403757A CRC64;
     MSTKTKPLLK ELLGSKPVSP RALFIMLDMT QKCESMLMEL AFRKSKMDEA AQKLVESMWI
     IDNSLAHAYR EREITDREHE LISAQAEAIT DCAHAIAKRK HPYEMDNDTE DWEEWINRSI
     RGTEKAIERH GALWCIGLGG VWELGVLDFD IIGKVFILSA RDTGRHKVYL NYFPFVENSS
     LYYAVQQVTK QETVQPYNDW PNDIGFNTTY EERTTVELEV KGHIPSWAAG VLYRVGTGAN
     EIDTEKGTRF RVNHWFDGHS VVHRFQIIAP DNEDGSVRVV YNSRSTCDGL IEKIRKTGNR
     EGMTFAAKYD PCTSYFKKTM SMFKSFRPTE MKPNERSVPV TVSVNFPGLP ASGPRHASGI
     ETLCSKTDAN VLQLLDPETL EPVGIASQTI LHPDLKGPMS CAHAKSDPIS GDVFNYNLEI
     GPTSTYRIFR VSASTGKTSI LATFNTSAAY IHSFFLTQNY VILCVWNSHY TANGATILLN
     QNVMDSISDY DPSRPSRWYV VDRRSPEEGG QGVVATYDSD PFYCFHTVNA YEQPSADGEG
     VDIIADLDSY SSHHVMKRFF LENLYSTSPK AAKHADPADA STRAEYKRFR LPSIPSSATQ
     VRQKAVLEFI GCPFDTPELP TINPSYVLRR HRYVYGIADT GKASFLDGLI KYDTKTKTAV
     FWSEHGQSAG EAIFIPREPG VVSEDGEGED DGVLLTVVLD GPVGRSYLLV LDAKTMKEIG
     RAEMKGAAGF GFHGTHISAR GSRGVGGEMG RGLDF
//