ID V5FM41_BYSSN Unreviewed; 722 AA.
AC V5FM41;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Sorting nexin MVP1 {ECO:0000256|ARBA:ARBA00014268};
GN ORFNames=PVAR5_7745 {ECO:0000313|EMBL:GAD99039.1};
OS Byssochlamys spectabilis (strain No. 5 / NBRC 109023) (Paecilomyces
OS variotii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX NCBI_TaxID=1356009 {ECO:0000313|EMBL:GAD99039.1, ECO:0000313|Proteomes:UP000018001};
RN [1] {ECO:0000313|Proteomes:UP000018001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=No. 5 / NBRC 109023 {ECO:0000313|Proteomes:UP000018001};
RX PubMed=24407650; DOI=10.1128/genomeA.01162-13;
RA Oka T., Ekino K., Fukuda K., Nomura Y.;
RT "Draft genome sequence of the formaldehyde-resistant fungus Byssochlamys
RT spectabilis No. 5 (anamorph Paecilomyces variotii No. 5) (NBRC109023).";
RL Genome Announc. 2:E0116213-E0116213(2014).
CC -!- FUNCTION: Required for vacuolar protein sorting.
CC {ECO:0000256|ARBA:ARBA00002474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD99039.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BAUL01000274; GAD99039.1; -; Genomic_DNA.
DR AlphaFoldDB; V5FM41; -.
DR eggNOG; KOG2273; Eukaryota.
DR HOGENOM; CLU_009058_1_0_1; -.
DR InParanoid; V5FM41; -.
DR OrthoDB; 45524at2759; -.
DR Proteomes; UP000018001; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07597; BAR_SNX8; 1.
DR CDD; cd06866; PX_SNX8_Mvp1p_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR035704; SNX8/Mvp1_PX.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR47554; SORTING NEXIN MVP1; 1.
DR PANTHER; PTHR47554:SF1; SORTING NEXIN MVP1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000018001};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 342..457
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 36..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 79650 MW; 7CC55106F17689E0 CRC64;
MSLFGTSPEE SSPGNSALRS KSSLFADDAG FGAGSGSSLF ADDAGDDSPW SNNTLPKRAA
RRDLVKTLLP ATDVPESYID AYDLVLNSGP RVGAGVGLTG VREILASSGL NATDQARILN
LVVPGEQENE NGLERNEFNV LLALVGLAQE GEDITLDSVD ERRKKLPQPK ITYLDRLRDQ
GDSNNNPPQS RERAVTPPRS IAPQEPGSSR SQRPRRNSLG GLESDPWGSP DLHRNHHHAQ
EGENAPVANG YGSLRSAADR WGNQAGHTEQ SGSTNGTGVN GQTDAAPPST SGSSWGGAGD
GFGNPGQSGL GEFGQLGDEQ GGPNPPRRSI GGRMTGTATG PEEVITVTLL PEKEGLFMFQ
HRNYEVKSAR RGSSVVRRYS DFVWLLDCLH KRYPFRQLPL LPPKRVAVNG THLAADSSSF
LEKRRRGLVR FANALVRHPV LSQEQLVVMF LTVPTELSVW RKQATISVQD EFTGKALPPD
LEDSLPPNLT ELFDTVRAGV KRSAEIYINL CTLLERLAKR NEGLAADHLR FSLALQSLTE
VTKDTYAVDT NDVPLLNEGI SATARHLSAS QTLLEDEAKT WHEGVLEDLK RQRDCLVSMR
ELFDRRDRYA RDNIPQLERR IENNERKLQD LRNRPQGTGK PGDVEKIEDA IFKDKESIVQ
QHARGVFIKE CIRDELIYFQ SSQYHISHLH QDWSQERVKY AELQADNWRT LSEEVDGMPT
GE
//
