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Database: UniProt
Entry: V5GDP9_BYSSN
LinkDB: V5GDP9_BYSSN
Original site: V5GDP9_BYSSN 
ID   V5GDP9_BYSSN            Unreviewed;       587 AA.
AC   V5GDP9;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=SIR2 family histone deacetylase (Hst4), putative {ECO:0000313|EMBL:GAE00212.1};
GN   ORFNames=PVAR5_8950 {ECO:0000313|EMBL:GAE00212.1};
OS   Byssochlamys spectabilis (strain No. 5 / NBRC 109023) (Paecilomyces
OS   variotii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX   NCBI_TaxID=1356009 {ECO:0000313|EMBL:GAE00212.1, ECO:0000313|Proteomes:UP000018001};
RN   [1] {ECO:0000313|Proteomes:UP000018001}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=No. 5 / NBRC 109023 {ECO:0000313|Proteomes:UP000018001};
RX   PubMed=24407650; DOI=10.1128/genomeA.01162-13;
RA   Oka T., Ekino K., Fukuda K., Nomura Y.;
RT   "Draft genome sequence of the formaldehyde-resistant fungus Byssochlamys
RT   spectabilis No. 5 (anamorph Paecilomyces variotii No. 5) (NBRC109023).";
RL   Genome Announc. 2:E0116213-E0116213(2014).
CC   -!- SIMILARITY: Belongs to the sirtuin family. Class I subfamily.
CC       {ECO:0000256|ARBA:ARBA00006924}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAE00212.1}.
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DR   EMBL; BAUL01000393; GAE00212.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5GDP9; -.
DR   eggNOG; KOG2684; Eukaryota.
DR   HOGENOM; CLU_021544_2_1_1; -.
DR   InParanoid; V5GDP9; -.
DR   OrthoDB; 1327719at2759; -.
DR   Proteomes; UP000018001; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1600.10; SIR2/SIRT2 'Small Domain; 1.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   PANTHER; PTHR47651; NAD-DEPENDENT HISTONE DEACETYLASE HST4; 1.
DR   PANTHER; PTHR47651:SF2; NAD-DEPENDENT HISTONE DEACETYLASE HST4; 1.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00236};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018001};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00236}.
FT   DOMAIN          78..403
FT                   /note="Deacetylase sirtuin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50305"
FT   REGION          1..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          409..495
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          525..587
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..37
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..61
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..449
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        228
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         236
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         239
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         258
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         261
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
SQ   SEQUENCE   587 AA;  64353 MW;  E92CDD8B14BDF879 CRC64;
     MQPSRSAMDI DDDTDTSDLS SPPSSPHPPP GFYPSPPPSQ DQDADDSSAA RSQDERPAKK
     RRRVEPKPRT TQHLDLSRND QQSYVQQHAQ RELLKKTLRK HRKIVVIAGA GISTSAGIPD
     FRSTDGLFKS VQKKHNLKSS GKLLFDAAVY RDDSLTASFH EMVRSLSEEA AKSTPTAFHH
     LLARLAKENR LSRLYTQNID CIETSMPPLA TQVPLNNKAP WPRTIQLHGS LDKMVCQKCR
     HLSEFQRELF DGPDAPLCPA CSETDAFRAE TGQRSHGVGK MRPRIVLYNE HNPDEEAIAS
     VMNADIRSRP DALIVVGTSL KIPGVRRLVK DMCTVVRGRR NGVTMWINND LPVGKEFEDC
     WDLMVTGDCE EVARLAGLKR WDDDSENVFD ECDASEVERV KKQHGGFSVV VPSTPRKQQK
     TNTGFLTPSS SHDEMAGVSQ TQSPAPRANP ASRGPSINDV LRGSKTTNPK KPGPKKGAAN
     KTTKTTKPRA KKEQTAKVTK ITSFSKVTKG SKAAAGTGKA IKLERDESAK PMHPLPPGAA
     RNNGPLFPNL ASKGDTSPCG ELWRNPGTIS PPRVPKGMTD LLSDPSA
//
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