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Database: UniProt
Entry: V5GK07_KALBG
LinkDB: V5GK07_KALBG
Original site: V5GK07_KALBG 
ID   V5GK07_KALBG            Unreviewed;       339 AA.
AC   V5GK07;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   05-JUN-2019, entry version 19.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:EST06302.1};
GN   ORFNames=PSEUBRA_SCAF3g03818 {ECO:0000313|EMBL:EST06302.1};
OS   Kalmanozyma brasiliensis (strain GHG001) (Yeast) (Pseudozyma
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Kalmanozyma.
OX   NCBI_TaxID=1365824 {ECO:0000313|EMBL:EST06302.1, ECO:0000313|Proteomes:UP000019377};
RN   [1] {ECO:0000313|Proteomes:UP000019377}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GHG001 {ECO:0000313|Proteomes:UP000019377};
RX   PubMed=24356824; DOI=10.1128/genomeA.00920-13;
RA   Oliveira J.V.D.C., dos Santos R.A.C., Borges T.A., Riano-Pachon D.M.,
RA   Goldman G.H.;
RT   "Draft genome sequence of Pseudozyma brasiliensis sp. nov. strain
RT   GHG001, a high producer of endo-1,4-xylanase isolated from an insect
RT   pest of sugarcane.";
RL   Genome Announc. 1:E0092013-E0092013(2013).
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DR   EMBL; KI545873; EST06302.1; -; Genomic_DNA.
DR   RefSeq; XP_016291291.1; XM_016437755.1.
DR   STRING; 1392244.V5GK07; -.
DR   EnsemblFungi; EST06302; EST06302; PSEUBRA_SCAF3g03818.
DR   GeneID; 27420433; -.
DR   OrthoDB; 938257at2759; -.
DR   Proteomes; UP000019377; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000019377};
KW   NAD {ECO:0000256|PIRSR:PIRSR000105-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019377}.
FT   DOMAIN       38    226       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      229    333       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   NP_BIND      43     48       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   REGION      319    339       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V5GK07}.
FT   BINDING      67     67       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING      83     83       Coenzyme A. {ECO:0000256|PIRSR:
FT                                PIRSR000105-3}.
FT   BINDING      90     90       Coenzyme A. {ECO:0000256|PIRSR:
FT                                PIRSR000105-3}.
FT   BINDING     133    133       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     138    138       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     160    160       Coenzyme A. {ECO:0000256|PIRSR:
FT                                PIRSR000105-3}.
FT   BINDING     160    160       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     186    186       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     323    323       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   SITE        183    183       Important for catalytic activity.
FT                                {ECO:0000256|PIRSR:PIRSR000105-1}.
SQ   SEQUENCE   339 AA;  36342 MW;  1BC18FAC7DD4B87D CRC64;
     MMLQTSRIAL RGAFAASMSR SATRAFSTSM VQNKDVQNIT VFGAGLMGAG IAQVLAHKGK
     FNVTLSDVTD KALSNGQNII SKSLGRIAKK SMAEASADEQ AKFVKGVVDS IKVTTDPAAA
     VKDTDLVIEA IIENVGIKKD LFGFLDGKAP RDALFASNTS SLSITDVAEA VSAERQERFG
     GFHAFNPVPQ MKLVEVIRTT KTSNDTFDSL YEVAKRMGKT PVACIDSPGF IVNRLLVPYM
     LEAIRLVERG EATAKDVDIA MKLGAGYPMG PFELADLVGL DTLSHIAKGW RETRVKTGEI
     TAEAVSESKL LEDLVKQGKL GKKSGEKGGF YEYPAPAKK
//
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