ID V5IKV1_NEUCR Unreviewed; 2567 AA.
AC V5IKV1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Polyketide synthase 4 {ECO:0000313|EMBL:ESA41864.1, ECO:0000313|EMBL:ESA41865.1};
GN Name=pks-4 {ECO:0000313|EMBL:ESA41865.1};
GN ORFNames=NCU08399 {ECO:0000313|EMBL:ESA41865.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:ESA41865.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:ESA41865.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805}, and OR74A
RC {ECO:0000313|EMBL:ESA41865.1};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [2] {ECO:0000313|EMBL:ESA41865.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OR74A {ECO:0000313|EMBL:ESA41865.1};
RG The Broad Institute Genome Sequencing Platform;
RA Galagan J., Henn M.R., Hood H., Radford A., Collins R.A., Walker B.,
RA Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA Allen A.W., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B., Chen Z.,
RA Gainer-Dewar J., Gnerre S., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J.B., McCowan C., Murphy C.,
RA Pearson M.D., Poon T.W., Priest M., Roberts A., Saif S., Shea T.D.,
RA Sisk P., Shea T., Sykes S., Zucker J., Kodira C., Bowman B., Colot H.,
RA Ebbole D., Rasmussen C., Baker C., Kalkman E., Chen C.-H., Shi M.,
RA Mathur R., Lambreghts R., Collopy P., Mehra A., Schweredtfeger C., Hong C.,
RA Belden W., Glass N.L., Borkovich K., Dunlap J., Lander E., Wortman J.,
RA Nusbaum C., Sachs M., Birren B.;
RT "The Genome Sequence of Neurospora crassa strain OR74A.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CM002242; ESA41864.1; -; Genomic_DNA.
DR EMBL; CM002242; ESA41865.1; -; Genomic_DNA.
DR RefSeq; XP_011395279.1; XM_011396977.1.
DR RefSeq; XP_011395280.1; XM_011396978.1.
DR STRING; 367110.V5IKV1; -.
DR PaxDb; 5141-EFNCRP00000007812; -.
DR EnsemblFungi; ESA41864; ESA41864; NCU08399.
DR EnsemblFungi; ESA41865; ESA41865; NCU08399.
DR GeneID; 3879386; -.
DR KEGG; ncr:NCU08399; -.
DR VEuPathDB; FungiDB:NCU08399; -.
DR HOGENOM; CLU_000022_31_0_1; -.
DR InParanoid; V5IKV1; -.
DR OMA; HMFLEAI; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IBA:GO_Central.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..448
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2389..2466
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2476..2509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2535..2555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2479..2509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2567 AA; 280737 MW; D6A8425231E7AF4F CRC64;
MSYKIPLSEP IAIVGSSCRF TGEATSPAKL WELLKDPKDL TREVPKDRFN VEGFYHPDGE
YHGTTNSAKA YFLEQDHRLF DASFFNITPK EAEAIDPQQR MLLEVVYEAL ESAGYTLQDY
SGKKVAVFAG VMTADYDTLS QRDDLSVSQY YATGNARSII SNRVSYFFNF HGPSMTIDTA
CSSSLVALHQ AVLSLRSGEA EMACVSGVNL ILTPEQFVVE SSLHMLSPTG RCHMWDDRAD
GYARGEGVAA IFIKPLSKAL ADGDRIEAII RETGVNSDGR SKGITMPNWE AQSALIQDTY
RRSGLNARDP IDRCQFFEAH GTGTAAGDPN EARAIEDAFF GRNVSTSSQD TAEVSKLLVG
SVKTVIGHTE GAAGLAGLFK VVHAMINGTV PPNLHFNRLQ PAVAKYYSHL HVPTKALAWP
SVAAGQPRRA TVNSFGFGGT NSTAICEMYV PEIHDPVAKI FAPTLIVPKL INSGSLSADG
QTRLPLVLSA SSPRSMGAVA KCYRDYLAQV SLPLEEAAWY AYKNRTAFPY RTAVSGSSLS
DIMKGLDTLI AKAEAGKAAT ISVRARPETD VPKILGIFTG QGAQWATMSR GLLQSNNVYA
QSIRNLDQVL QACPHPPSWF LEQEIMADAS LSRVGKAAIS QPLCTAVQIA LIDLLAHLGI
TFHTVVGHSS GEIAAAYAAG KLSARDSILI SYYRGKYAHL ASGAQGSLGG MMAAGLTKAE
AEELCALPQF GNRVCVAASN GPSSVTLSGD LDIVQKVHDH LVDEKKFARM LQVDTAYHSP
HMVRPANEYI EALKACNIAP LQDGNGTTWV SSVYGHGEPT SEELASSYWR DNMVNAVLFF
EAVSTALEGQ GPFDCAIEVG PHAALRGPVI QTMKAKSGEA IIYSGLLDRK LDDRIAFADF
LGWMWSNFGS SSSLIERFVQ SSVNPELAHL RFQQGPNYPW DHSHTYYRES RISRQYHFRT
HKPHELLGIR TRDDNEHELR WRNIMKYAKL PWAQGHKFQG QALLPASAYC IMVLDAARVL
SGNRAASVVE LRDLKFMAGI TLEPESPGVE TLFSLVVSNS PKNASTIEAL FTLTSAPADG
TIDMKLNFSG QLHIVLGEKS PNALSRRPAQ RAETLTAQPE AFYKMMAGTG LDYNGPFKGL
TAIERRYQFS SGTVKRFHAD DQTGLDISPA TLDSCLQTAF LTVSSPGDGS LWTSFLPKVM
SRVKFNLATC RSGGRDDNLV VDAYLTKGTP FSKTAAASFT AEINIFNPEG NLEIQIEGLT
VGSFTSTRPE NDKELYLTTV YELDPEDEIV ASPAEALNGV SPMLFESCAR VASFYVERAA
LKRLKETPRD LLEPAGYQTE TRLVSNSWPN ETEQSLEKFI RSSPYFMTLD FVRHLGENLP
DVLPGMLPTL VQEAQQLAYF QKQVGRVVRQ IVHKYPRMNI LGLTDPELGL TEHLMAALDG
SFLSYRIGGK PETNLKERSP LAEGIRKKIM IDEIDFEGDA ESVGGPYDLV VLNTSILEDK
KTHSALQLIR DSMRPGGFLV VVHASRTPLK ERMLRCAGRT SSNDGIATPP DWPDLIEECG
FENTAKNSDM WFHPGFTLSV RQAMSQRKKQ LLWPLHHATG TPLVKHLLIV GGKKVWTSCI
SSGVFQELAS FCGKITAVDS LEDIHNDELL SSCTAAIILG DIDQPILADM TAERMDTIRS
LLRPQMLIMW VTHNARFDNP DHAASLGFTR TVTGEVPGLH IQVLDLDTID TCPAVRAVSK
TFARFIVHFL GPKNEDDEPL WVREHEVHVE GGRLIVPRVL PWKEGNQRVN APRRVMTDTV
NTLEDVVEVL ASASGRYETR VEKSEAYPSH VESAMHVDYS TVKVFNIGAI CSGHICIGRN
NETGKAQVAL SKSNKSFIST ASTIFSTLPE GTVGVCEPLY LSLLSRYIYA LTIVNMANGR
SVMIIEPDGL LFQCAKEVCS NRGIWFMGAS TDERRSRVVP DIAFVHSQST SRQIKALYPL
DGACIVNMLP KTHDVSRMLV DSVPENCEYL TQDKLISTHF TAHPNAAFVQ KLWEEAVTLS
YNSMKSMLLN AIEPSFDILD PITLPKLLDS AVSSEAFQML DWKAERSIAH MIKPIVGEKM
LRPNSTYVLV GITRDMGQSL CSLFIEQGAR HLVLCSRNPP KEQPQWQKEL NARGIKVKFE
AMDVTNLNTV IAFKTKLAED SWPSVGGVVN GAMVLDDRVF SEMSVETWNR VMNPKVVGSR
NLDIVFNSPD MDFFIMTSSF AAIGGHAGQS NYAAANMYMN GIAASRRCRG LPATALNIGV
VYGLGFLHRE KDDLYAGLER EGYPPISERD LHHMFLEAIA AGKPVGHTVY DITTGMNRFR
MDAPNQHWQL DPRFSHNTLP EEDETAAGSA GQQIKSLAED LDAATTKEDV MKVYVPAFIG
RLEALLQIAE GEITPANSVT ELGVDSLIAV EIRSWIWKTV AQDVAVMKIL SATSIAQLCE
GIASDLLVAR GAAAKDSTAP TEQKETPAGS QTLQAVSGSV KSAPSTTPSL EASASTLTEA
TVVSIVSTST VVSSASTATS VDGDAEEDNA LSASWEDVGK KESSIFL
//