ID V5ILU5_NEUCR Unreviewed; 364 AA.
AC V5ILU5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Ribose-5-phosphate isomerase {ECO:0000256|ARBA:ARBA00019150};
DE EC=5.3.1.6 {ECO:0000256|ARBA:ARBA00011959};
DE AltName: Full=D-ribose-5-phosphate ketol-isomerase {ECO:0000256|ARBA:ARBA00032273};
DE AltName: Full=Phosphoriboisomerase {ECO:0000256|ARBA:ARBA00029734};
GN Name=ppm-3 {ECO:0000313|EMBL:ESA42758.1};
GN Synonyms=ppp-4 {ECO:0000313|EMBL:ESA42758.1};
GN ORFNames=NCU07608 {ECO:0000313|EMBL:ESA42758.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:ESA42758.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:ESA42758.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate;
CC Xref=Rhea:RHEA:14657, ChEBI:CHEBI:58121, ChEBI:CHEBI:58273;
CC EC=5.3.1.6; Evidence={ECO:0000256|ARBA:ARBA00001713};
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribose
CC 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step
CC 1/1. {ECO:0000256|ARBA:ARBA00004988}.
CC -!- SIMILARITY: Belongs to the ribose 5-phosphate isomerase family.
CC {ECO:0000256|ARBA:ARBA00008088}.
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DR EMBL; CM002239; ESA42758.1; -; Genomic_DNA.
DR RefSeq; XP_011394247.1; XM_011395945.1.
DR AlphaFoldDB; V5ILU5; -.
DR PaxDb; 5141-EFNCRP00000007691; -.
DR EnsemblFungi; ESA42758; ESA42758; NCU07608.
DR GeneID; 3878996; -.
DR VEuPathDB; FungiDB:NCU07608; -.
DR OrthoDB; 5232260at2759; -.
DR UniPathway; UPA00115; UER00412.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0004751; F:ribose-5-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; IEA:InterPro.
DR CDD; cd01398; RPI_A; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.40.50.1360; -; 1.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR004788; Ribose5P_isomerase_type_A.
DR NCBIfam; TIGR00021; rpiA; 1.
DR PANTHER; PTHR11934; RIBOSE-5-PHOSPHATE ISOMERASE; 1.
DR PANTHER; PTHR11934:SF0; RIBOSE-5-PHOSPHATE ISOMERASE; 1.
DR Pfam; PF06026; Rib_5-P_isom_A; 1.
DR SUPFAM; SSF75445; D-ribose-5-phosphate isomerase (RpiA), lid domain; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ESA42758.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ESA42758.1"
SQ SEQUENCE 364 AA; 38486 MW; 181238D95F177953 CRC64;
MNPHRVTSCI PRRSWSAAAA AARCVHQPGP AFHSAAAAAA NFKFNPSTSA PPLRTTIVLQ
AALPNTFTTQ PHRNLHITTA KMSTAPDASA AQQLIEKSKF LAANRAVTEH LSPTYRHIGI
GSGSTVIHVV DVISKLGTTI TGPMTFYPTG DQSRDLIQAA GFRLGYLSDL SPGHALDVCF
DGADEVDPAL NLIKGGGACL LQEKLVATAA RKFVCVADSR KISNHLGTQW KKGIPIEVFP
MAVPQVLGEL ERLGRLSAQV RSGLPGKAGA CVTDNGLRIV DAVFKPLLTE LPEGKQEGEE
GVWTVDGLAR RLIEIPGVAE HGLFYGKSGL EVESGGAQKP VAAYFGMEDG SVMVQTLENG
LVKA
//
