ID V5INF9_NEUCR Unreviewed; 481 AA.
AC V5INF9;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Aspartyl proteinase {ECO:0000313|EMBL:ESA42682.1, ECO:0000313|EMBL:ESA42683.1};
DE SubName: Full=Aspartyl proteinase, variant 2 {ECO:0000313|EMBL:ESA42684.1};
GN ORFNames=NCU04269 {ECO:0000313|EMBL:ESA42684.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:ESA42684.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:ESA42684.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805}, and OR74A
RC {ECO:0000313|EMBL:ESA42684.1};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [2] {ECO:0000313|EMBL:ESA42684.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OR74A {ECO:0000313|EMBL:ESA42684.1};
RG The Broad Institute Genome Sequencing Platform;
RA Galagan J., Henn M.R., Hood H., Radford A., Collins R.A., Walker B.,
RA Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA Allen A.W., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B., Chen Z.,
RA Gainer-Dewar J., Gnerre S., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J.B., McCowan C., Murphy C.,
RA Pearson M.D., Poon T.W., Priest M., Roberts A., Saif S., Shea T.D.,
RA Sisk P., Shea T., Sykes S., Zucker J., Kodira C., Bowman B., Colot H.,
RA Ebbole D., Rasmussen C., Baker C., Kalkman E., Chen C.-H., Shi M.,
RA Mathur R., Lambreghts R., Collopy P., Mehra A., Schweredtfeger C., Hong C.,
RA Belden W., Glass N.L., Borkovich K., Dunlap J., Lander E., Wortman J.,
RA Nusbaum C., Sachs M., Birren B.;
RT "The Genome Sequence of Neurospora crassa strain OR74A.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
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DR EMBL; CM002240; ESA42682.1; -; Genomic_DNA.
DR EMBL; CM002240; ESA42683.1; -; Genomic_DNA.
DR EMBL; CM002240; ESA42684.1; -; Genomic_DNA.
DR RefSeq; XP_011394644.1; XM_011396342.1.
DR RefSeq; XP_011394645.1; XM_011396343.1.
DR RefSeq; XP_011394646.1; XM_011396344.1.
DR AlphaFoldDB; V5INF9; -.
DR STRING; 367110.V5INF9; -.
DR PaxDb; 5141-EFNCRP00000003918; -.
DR EnsemblFungi; ESA42682; ESA42682; NCU04269.
DR EnsemblFungi; ESA42683; ESA42683; NCU04269.
DR EnsemblFungi; ESA42684; ESA42684; NCU04269.
DR GeneID; 3877392; -.
DR KEGG; ncr:NCU04269; -.
DR VEuPathDB; FungiDB:NCU04269; -.
DR HOGENOM; CLU_013253_0_2_1; -.
DR InParanoid; V5INF9; -.
DR OMA; WYGGVQS; -.
DR OrthoDB; 2900143at2759; -.
DR Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd06097; Aspergillopepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR034163; Aspergillopepsin-like_cat_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966:SF1; ASPARTYL PROTEINASE; 1.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT DOMAIN 106..433
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 76..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 124
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 324
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
SQ SEQUENCE 481 AA; 53084 MW; 248C2FE9535F6CBC CRC64;
MGSMYQVQSK LRQDLGLHKV QAVRKPGREL NGTKAYVSAM ARYGFNPTEE SRFFHLKKTD
LTKEFQRRGY IRHWEQLVRT PQERPDDPHT DNEPVPAEDQ QYDTQYLCEI GIGTPQQKVK
LDFDTGSADL WVRCTDSSLL HHADKKFDPK KSDTFQESKT DQTWKIQYGD GSTASGTVGT
DVITVGGLQI KNQAIELAKK VSSAFSSGEA DGLLGLAFST INTIESDGKP DPQPTPVENM
ISQEDIPKEA ELFTSAFYSA RDDKSEEKSF YTFGWVDEDL VKASGKDITW TPIDNSEGFW
KFPSESATVD GDNVSVSGNT AIADTGTTLA LVSDTVCKAL YAKIPGSKYS YRYQGYLIPS
TITADQLPQL SVAVGGEQFV IQNEDLLLAP ADDDHWYGGV QSRGTMPFDI LGDTFLKSIY
AIWDQGNNRF GAVPKIEVNQ HTVFPDTEPS PEASSPEPAD KVGDVSPVEQ VKGAVKSLKV
L
//
