ID V5IQ08_NEUCR Unreviewed; 1744 AA.
AC V5IQ08;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Rho guanyl nucleotide exchange factor {ECO:0000313|EMBL:ESA43805.1};
GN Name=rgf3 {ECO:0000313|EMBL:ESA43805.1};
GN ORFNames=NCU02131 {ECO:0000313|EMBL:ESA43805.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:ESA43805.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:ESA43805.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
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DR EMBL; CM002236; ESA43805.1; -; Genomic_DNA.
DR RefSeq; XP_011392943.1; XM_011394641.1.
DR STRING; 367110.V5IQ08; -.
DR PaxDb; 5141-EFNCRP00000001344; -.
DR EnsemblFungi; ESA43805; ESA43805; NCU02131.
DR GeneID; 3880429; -.
DR VEuPathDB; FungiDB:NCU02131; -.
DR InParanoid; V5IQ08; -.
DR OrthoDB; 2734900at2759; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT DOMAIN 919..1111
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1146..1314
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1381..1690
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1744 AA; 192557 MW; F0C30A62DE5A005A CRC64;
MSFRGDDSRR YGHVPPAQYP VAGAAQDNSN SPYPPQRRMS FNTGDDAAMF DPSAARQQPA
IYTGVPVVGR AEEELFLGSP TSQDAPAAQN RLSYKSQHIA MAGYQHQYQA QTSAPPPAPA
HSTYNPQAFA RTQSTSLPYH PAPASRYGAP TSPTYAPTPT TYTPPAYNPA AYANTNTATP
QRHSSVASVA SSGYNGYTYG YTSPGIPQSG FGQSPQSATA PSISSYEPAR SPQYPPSSAT
ATSPQYDQSY PPANAYNTQQ YYGSYPVNAS GMAYNTMTSQ APYPTAHAQM PAGPSYASAD
HAAFSGRNSR SDSQVSAPSP PPHSQAPGGL TRHPTNAPLP SRPMDDLPEH HSWGPNGQSN
ELQTQDALFG DIISEVEPRQ YRGVNGNISE DDQGLHRYSS TASTNVGSAA AVHRYPSNAS
TVNRNDIPDT YPNTYDYDDD ESDPEGAAGL LAMQEDMDDR RFGFGGISFP TYMEPPAAQQ
QTSPTHPIQP PGHQRELPPP PEEQGTESDF GGMDLGLYGG GYAGNLHYGN EVGSPPATSA
HFDQGPRPLP YPQNTGSEYA PFSQAAVDYG GTGGLQAPQT HRLSFDEGDE HVSIHSRHSG
SDSPTKEEYP DMFYHPGISN RPLPAVPPLG ESRPVLSVVP PSRVASQQGY NMDVNQRLMY
DQQGQAAVER SISLSSHSNT PPVHTPARSR TDAAEERRRA LKHANQHHSH LSHHSVSQDG
YDSGTPTSLA AYDMITLPGR KRKFIPSKLT ATEIKRCAEP WALSSVTAWI REMADGEVDL
KRKSIEEGIV KLFCHKVPTM NVADAESLSA TVVDSMFASG LLIPDEEWVR FGTGHMTGVL
WQLTGHGCYA PKLHEAEESA PKLNDNGIPV RCYSHHCGRT LKKANLDHLL SDDPVVQDWA
TFHGVKPEDC EKKSKKEIER QNVLHEIVTS EEEYMAQLDV VRLLYRDQLR VHQPPVLPNS
RRDKFLEAVF GKVDTVQQIN KDHLLAQLKY RQQEQAPFIV GFSDLFREWI RKARPIYIEY
CSSYPNSEYL IRKESNRNIL FREFLGHVQN HRRSKRLGWT TFVKAPITRL QRYSLLLSTV
LKNTIEDSEE KQNLIKAIDE IRSVTKECDD RVAEMTKKVS LLELQQQLVL RPGFQSVLNL
DHLGRELLKQ GELQRQGSKG VRWVDTQALL FDHYFILAKA VSTKDGRNEK KYDVSKEPIP
MPLLFLESMH DEPVTKQKGL AAPLTRTAAT AGSGTQLNKI ASNGGDRPGL EHSATSSSMG
SLTTVTRLTS SGVDDGKIIY PFRIKHLGHE IYTLYASSAL DRSEWCKAIV DAKTRHAEAL
HAQNAEPFRL RVLSDGAFAY DSYSTFGRQP GVPISGTPLD RAIRGMEEVY GKGRGPPPVC
RAQVNCATAF KSFGKSIIAI GTDYGVYISE ASNPRGWTRS VQISKVTQIA VLEDFSVCIL
ISDRSLISYP LDVIAPVSNF PSPVHDNPRR APQRLAKDVT FFATARMKDR TLLFYKRKEG
MHNTFKVLEP VFQKATEKKS RIFGSRKFGS GATESFRDYD EFYIPAECYS LNLFQSYIAV
ASAKGFELLT LDKKVTQSIP RDLNLPAIAN IASRIKDQRP LGMFKLNDQE FLLTYEDCAV
YVDKHGEISR TLIMEYSGKQ KKAKAATMFG QYLLLFNEDY VEVRNAENGR LRQIIAGRDV
RCLDYGFRGP TGSGQQHAQP HTLLQAGVLQ DTKGTVKICM SHPEVPGGQI VLEMLLNDGH
AEKA
//
