ID V5IQD4_NEUCR Unreviewed; 2182 AA.
AC V5IQD4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Dock180 protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=NCU09492 {ECO:0000313|EMBL:ESA43744.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:ESA43744.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:ESA43744.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805}, and OR74A
RC {ECO:0000313|EMBL:ESA43744.1};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [2] {ECO:0000313|EMBL:ESA43744.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OR74A {ECO:0000313|EMBL:ESA43744.1};
RG The Broad Institute Genome Sequencing Platform;
RA Galagan J., Henn M.R., Hood H., Radford A., Collins R.A., Walker B.,
RA Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA Allen A.W., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B., Chen Z.,
RA Gainer-Dewar J., Gnerre S., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J.B., McCowan C., Murphy C.,
RA Pearson M.D., Poon T.W., Priest M., Roberts A., Saif S., Shea T.D.,
RA Sisk P., Shea T., Sykes S., Zucker J., Kodira C., Bowman B., Colot H.,
RA Ebbole D., Rasmussen C., Baker C., Kalkman E., Chen C.-H., Shi M.,
RA Mathur R., Lambreghts R., Collopy P., Mehra A., Schweredtfeger C., Hong C.,
RA Belden W., Glass N.L., Borkovich K., Dunlap J., Lander E., Wortman J.,
RA Nusbaum C., Sachs M., Birren B.;
RT "The Genome Sequence of Neurospora crassa strain OR74A.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; CM002237; ESA43744.1; -; Genomic_DNA.
DR EMBL; CM002237; ESA43745.1; -; Genomic_DNA.
DR EMBL; CM002237; ESA43746.1; -; Genomic_DNA.
DR RefSeq; XP_011393643.1; XM_011395341.1.
DR RefSeq; XP_011393644.1; XM_011395342.1.
DR RefSeq; XP_011393645.1; XM_011395343.1.
DR STRING; 367110.V5IQD4; -.
DR PaxDb; 5141-EFNCRP00000009295; -.
DR EnsemblFungi; ESA43744; ESA43744; NCU09492.
DR EnsemblFungi; ESA43745; ESA43745; NCU09492.
DR EnsemblFungi; ESA43746; ESA43746; NCU09492.
DR GeneID; 3879306; -.
DR KEGG; ncr:NCU09492; -.
DR VEuPathDB; FungiDB:NCU09492; -.
DR HOGENOM; CLU_000595_0_1_1; -.
DR InParanoid; V5IQD4; -.
DR OMA; LWDNQAF; -.
DR OrthoDB; 8258at2759; -.
DR Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08679; C2_DOCK180_related; 1.
DR CDD; cd11684; DHR2_DOCK; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 7..87
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 586..767
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1415..1836
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 87..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1842..1887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1945..2037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2065..2182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1858..1887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1955..1978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1993..2037
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2065..2095
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2121..2152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2182 AA; 242023 MW; 7571C3399CF9BDE1 CRC64;
MPWQPLPRIA FAVATYPFTA SSAADLPLEI GDELYIIEET PDGNWLRGYL VAPPSLLAGL
TSVNGQTLEA RVFSGIFPRS CVEVREVLGE SDETDDSEPD DGEPNGEKKK RRSERVTKEG
RLSVPVQRDP NEPRPPAPVP MLKIGDETPT SAAEPLIDEI ASCLREWHST NLHGLLLSRQ
YEKLDTLSKL ITSLNLSRQQ FLHNVLTTWE YDNLREKTVW DLVRVNKLCG GEVIVRDPNA
RGRVMTGDDS VVEITQLQSV MSLLDEPPTT TPELTALHHL MVDIKMFAGA SNESTTLVLY
LATKAPGGRV TPLSESYIVD VPAGGQLTNL ARTSQMRTLF SDLSSADVGD VQSSKSELLL
VVKIRAPQSV VAAKPSSRSG APSNSSPQIS AKESKPPLTS GNKALRRSMV WANKNTRGAF
TRKNSDLEAL SEQAEEQQTS NEALESRDGG PPSTANSNRA GRSSMDGQSP PTTADRTVGV
GVLKLNSIMK QQGEEVEHVV NIWAPCSKFP SDRHGDSEEW DPLIKEICDI RSGHHERSRR
AERLQIRLRS FNNPDADALI KMTPTVLSGI CKTNKMGFSG APTKPRSDIY VTIDEAILTR
QTLLSRYGAS ATALPSSIHS TNLQITLEVR RANGERIDYC IYPSSKDEGL STWRSTAVDR
GDPWKQIVKL VLAPQDVHQS HIVMYLADAP NPPFAVAYLP LWDQQAFIHD GSHNLLLYKL
DENTSNAQAP AGGKGGYLSL PFASNFRDEH AEVTGPLAVL RIDTYLCSTR FSQDKVVLGL
LKGKDLPLEE VPDILKAFIF VPEIEVVKLL NDVLDALFGI LVHYTGHDDL EDLVFTALVR
VLDIVHDRRF NLAPLVDQYA ETRFNYPFAT PCLVRSFTRL LSKPTEPETS RKLRATFKVV
RHILKFITHA RGQQKEKEAG IGITTSNPGF TRHLRTIFKA LDALMRNQAP VLVGSQTLAV
QHFHTWLPEL TGLLTTEEIL HIAIDFMDSC SSVKGKLVLY KLVLIINYSK LDIFSHPEQR
SALSANTVRW IAPHWGHTDE VTEQWREQVR LCCSVLASQV EHLGPEIPDY IPKIIQSYLA
IQAAEKTPKN RLSLLFPTSY PFPAKPTAEE VVFDEALIEL SAVLSALSNS PSGMQLELAE
DDLNILVESC LRVLMSILQG ETFPPNWLSV HIFHHKSTMR MLQYLATLLL ESFLPHPDEA
ENFDTELWKM FFTTLLKLVG SPSLALETFP EQKRRAVWKI AGDVREHGAD LLRKTWEAIG
WETSLEERAR YGLSKMGGYQ VQYVPTLVGP IVELCLSVHE GLRRMAVEVL QTMIVSEWTL
SEDLSVIQME IIDCLDGYFK EKPLTESILQ KLFVSELLDR FEPLSKIPDE PLYTAIRKLM
GTVDEFLDLL VAVHGGDGSG ETSDLVHRLR LMEFLRDMQK EEIFIRYVHQ LASLQASSRN
YTEAGLALRL HADLYDWDPL KTTPALDDPC FPAQSHFERK ERIYFDMIRH FEDGHAWSCA
LAAYKELQAQ YESNIFDFAK LARTQRAIAT IYETIAHKTD KLIPKYFKVV YKGLGFPPSV
RDKAFVFEGA SPTERTAGFT DRMQEMYPSA QIITPSYDRD TAEYDVEGQF LIISAISPHR
DLTHTVFQRA RVPQIIRDYL ISSSPQTFSV STKRDTNGDV RDHYAEKTLY TTAEPFPTIL
KRSEIVEIKH VRLTAKETAL ERIVRKTGEM TAVEKKIAEG QAQGGEGSDE ATVMLLVDAV
SISVNPESEA SVSRYRELIP GMGSTTPITI RCGSDEDEDE EDAPPEIDAQ ENAIKMALVD
HAIMIKRCLA TFAKSPREMV RKHGQDLQKF FERTFAPEIA IFTPPPARAP HPSPGSERTG
GITPSPTWPR SPGPSAFNSA TGQHKHHLSA TASLANGHGL GISSNAQGHA HTASETTDVL
GEIVVSTGIS QPVSLRQGRG ARLSFLGGRR KDGNSPTAHQ LSSTGSIPHL LNGSEHNLAS
RSKSHEDMHA GSASATVMNT PTTNGDRSPS APSNVIQSRK EQQQQQTDNT QEGYGSIGKA
NRRSFLRGFS SSDKVHLINA INGVADSVGG NTDWQTEYSS PSISQPNLDS PLQSQSDQLD
RERERGAAAA ALNGVSVGGY GKKEKKSKKD KEDKEEDRDL KELKDKFHNG SASVKKRLSM
LKLGNMKKSG KGDGKMGALD EE
//
