ID V5IQM7_NEUCR Unreviewed; 888 AA.
AC V5IQM7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Spa2-like protein {ECO:0000313|EMBL:ESA44030.1, ECO:0000313|EMBL:ESA44031.1};
GN Name=spa2 {ECO:0000313|EMBL:ESA44030.1};
GN ORFNames=NCU03115 {ECO:0000313|EMBL:ESA44030.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:ESA44030.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:ESA44030.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805}, and OR74A
RC {ECO:0000313|EMBL:ESA44030.1};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [2] {ECO:0000313|EMBL:ESA44030.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OR74A {ECO:0000313|EMBL:ESA44030.1};
RG The Broad Institute Genome Sequencing Platform;
RA Galagan J., Henn M.R., Hood H., Radford A., Collins R.A., Walker B.,
RA Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA Allen A.W., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B., Chen Z.,
RA Gainer-Dewar J., Gnerre S., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J.B., McCowan C., Murphy C.,
RA Pearson M.D., Poon T.W., Priest M., Roberts A., Saif S., Shea T.D.,
RA Sisk P., Shea T., Sykes S., Zucker J., Kodira C., Bowman B., Colot H.,
RA Ebbole D., Rasmussen C., Baker C., Kalkman E., Chen C.-H., Shi M.,
RA Mathur R., Lambreghts R., Collopy P., Mehra A., Schweredtfeger C., Hong C.,
RA Belden W., Glass N.L., Borkovich K., Dunlap J., Lander E., Wortman J.,
RA Nusbaum C., Sachs M., Birren B.;
RT "The Genome Sequence of Neurospora crassa strain OR74A.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0007829|PDB:6LAG}
RP STRUCTURE BY NMR OF 84-217.
RX PubMed=32503980; DOI=10.1038/s41467-020-16712-9;
RA Zheng P., Nguyen T.A., Wong J.Y., Lee M., Nguyen T.A., Fan J.S., Yang D.,
RA Jedd G.;
RT "Spitzenkorper assembly mechanisms reveal conserved features of fungal and
RT metazoan polarity scaffolds.";
RL Nat. Commun. 11:2830-2830(2020).
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DR EMBL; CM002236; ESA44030.1; -; Genomic_DNA.
DR EMBL; CM002236; ESA44031.1; -; Genomic_DNA.
DR RefSeq; XP_011393082.1; XM_011394780.1.
DR RefSeq; XP_011393083.1; XM_011394781.1.
DR PDB; 6LAG; NMR; -; A=84-217.
DR PDBsum; 6LAG; -.
DR AlphaFoldDB; V5IQM7; -.
DR BMRB; V5IQM7; -.
DR SMR; V5IQM7; -.
DR STRING; 367110.V5IQM7; -.
DR PaxDb; 5141-EFNCRP00000002853; -.
DR EnsemblFungi; ESA44030; ESA44030; NCU03115.
DR EnsemblFungi; ESA44031; ESA44031; NCU03115.
DR GeneID; 3881132; -.
DR KEGG; ncr:NCU03115; -.
DR VEuPathDB; FungiDB:NCU03115; -.
DR HOGENOM; CLU_014631_0_0_1; -.
DR InParanoid; V5IQM7; -.
DR OMA; VPNKSIM; -.
DR OrthoDB; 1384359at2759; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0005826; C:actomyosin contractile ring; IBA:GO_Central.
DR GO; GO:1902716; C:cell cortex of growing cell tip; IBA:GO_Central.
DR GO; GO:0005078; F:MAP-kinase scaffold activity; IBA:GO_Central.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR InterPro; IPR039892; Spa2/Sph1.
DR PANTHER; PTHR21601:SF0; PROTEIN SPA2-RELATED; 1.
DR PANTHER; PTHR21601; SPA2 PROTEIN; 1.
DR Pfam; PF12205; GIT1_C; 1.
DR Pfam; PF08518; GIT_SHD; 2.
DR SMART; SM00555; GIT; 2.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:6LAG};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 118..148
FT /note="GIT Spa2 homology (SHD)"
FT /evidence="ECO:0000259|SMART:SM00555"
FT DOMAIN 177..207
FT /note="GIT Spa2 homology (SHD)"
FT /evidence="ECO:0000259|SMART:SM00555"
FT REGION 1..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 888 AA; 97879 MW; DF9CDBDA63DB915D CRC64;
MNVRNAPLSP ISQGAPSDWN HPPNDNNLGQ YNTPPDSANP AGAMNGGFSP MPQSPNGAPS
PPPSVGRSST GMYARSVKSQ SQQGENQELV LSDHYISLKR YLSATSRDGN PKPPPNKARD
KLQRLTEVQF LELSTDVYDE LKRREQVARR GPNAPPETAP PDFLLPQDNF HPKRNQARQK
LSSLGPPRFR DLATDVFCEL ERRYPNFANL EMPLNASPIA MRGPPSRSGT PNNGMGGFPP
RGQSHRRPSE ASSVRSARSG PPMPPMMNGG YGVPPSPGLP PNGDYGRPMP KQFQSNTIVP
NKSTMVEEDD EGNLMSPGQG GDMYGNGRRS MGQAFEADRK LIQDYENQVR ELQEKVDNME
MEMRKKDEEL NNMQSGDGNK KDWDETRQSL ETKLAEAQEL NDSLQRELDR IREEHEDETR
KLREGLEDGR QSGGKGDGDL ARENEELRQS LQEQQQITDE VRREAQEFLR EMRTLSQQSG
AAWERQTELE RTIESLEKEV KEWRSRYART QTQLRSMRDS SEGVPLEQNA GKYVREKGFV
EDSGLVKDLH VTKFQIAIDE LLQRARNDNP ERVIDSMKAV VVSVRRIAKD IDENPQNDSI
LQEKAKLKAR VSSTANNLIT ASKNFASSAG ISPVSLLDAA ASHLVAAVIE LLRAAKIRTT
PAGELEEEDD GTVTPVGSAS FFSPRNGQSQ TSSVASAHEV LAQPPAFQGL GGGGGSRISV
DSSAYSANSP RESYAESKPT APDPRRVEDL KFYLQDKTSV MVETIQNLVQ LIRSDANINQ
LSGEIAIITD VVSKVVAETD SCLGSSASST VVDVVRRLSK CSDRLNEAGQ HGIDLDAQGS
SPTSREWRMW AQTLPPIAFE LARDTKELVQ QVDRLAAAGM NDGADDFA
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