ID V5RHY1_SPIAP Unreviewed; 437 AA.
AC V5RHY1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=GTPase Der {ECO:0000256|ARBA:ARBA00020953, ECO:0000256|HAMAP-Rule:MF_00195};
DE AltName: Full=GTP-binding protein EngA {ECO:0000256|HAMAP-Rule:MF_00195};
GN Name=engA {ECO:0000313|EMBL:AHB36149.1};
GN Synonyms=der {ECO:0000256|HAMAP-Rule:MF_00195};
GN ORFNames=SAPIS_v1c03030 {ECO:0000313|EMBL:AHB36149.1};
OS Spiroplasma apis B31.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=1276258 {ECO:0000313|EMBL:AHB36149.1, ECO:0000313|Proteomes:UP000018550};
RN [1] {ECO:0000313|EMBL:AHB36149.1, ECO:0000313|Proteomes:UP000018550}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B31 {ECO:0000313|EMBL:AHB36149.1};
RX PubMed=24407648;
RA Ku C., Lo W.S., Chen L.L., Kuo C.H.;
RT "Complete Genome Sequence of Spiroplasma apis B31T (ATCC 33834), a
RT Bacterium Associated with May Disease of Honeybees (Apis mellifera).";
RL Genome Announc. 2:e01151-13(2014).
CC -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC ribosome biogenesis. {ECO:0000256|HAMAP-Rule:MF_00195,
CC ECO:0000256|RuleBase:RU004481}.
CC -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000256|HAMAP-
CC Rule:MF_00195}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngA (Der) GTPase family.
CC {ECO:0000256|ARBA:ARBA00008279, ECO:0000256|HAMAP-Rule:MF_00195,
CC ECO:0000256|PROSITE-ProRule:PRU01049, ECO:0000256|RuleBase:RU004481}.
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DR EMBL; CP006682; AHB36149.1; -; Genomic_DNA.
DR RefSeq; WP_023789083.1; NC_022998.1.
DR AlphaFoldDB; V5RHY1; -.
DR STRING; 1276258.SAPIS_v1c03030; -.
DR KEGG; sapi:SAPIS_v1c03030; -.
DR PATRIC; fig|1276258.3.peg.298; -.
DR eggNOG; COG1160; Bacteria.
DR HOGENOM; CLU_016077_6_2_14; -.
DR OrthoDB; 9805918at2; -.
DR Proteomes; UP000018550; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR CDD; cd01894; EngA1; 1.
DR CDD; cd01895; EngA2; 1.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_00195; GTPase_Der; 1.
DR InterPro; IPR031166; G_ENGA.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR016484; GTPase_Der.
DR InterPro; IPR032859; KH_dom-like.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR NCBIfam; TIGR03594; GTPase_EngA; 1.
DR NCBIfam; TIGR00231; small_GTP; 2.
DR PANTHER; PTHR43834; GTPASE DER; 1.
DR PANTHER; PTHR43834:SF6; GTPASE DER; 1.
DR Pfam; PF14714; KH_dom-like; 1.
DR Pfam; PF01926; MMR_HSR1; 2.
DR PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51712; G_ENGA; 2.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|HAMAP-
KW Rule:MF_00195};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00195}; Reference proteome {ECO:0000313|Proteomes:UP000018550};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU004481};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517, ECO:0000256|HAMAP-
KW Rule:MF_00195}.
FT DOMAIN 5..168
FT /note="EngA-type G"
FT /evidence="ECO:0000259|PROSITE:PS51712"
FT DOMAIN 176..352
FT /note="EngA-type G"
FT /evidence="ECO:0000259|PROSITE:PS51712"
FT BINDING 11..18
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195"
FT BINDING 58..62
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195"
FT BINDING 120..123
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195"
FT BINDING 182..189
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195"
FT BINDING 229..233
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195"
FT BINDING 294..297
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195"
SQ SEQUENCE 437 AA; 49509 MW; DBF39D5778F3201C CRC64;
MSRKGVVAIV GRPNVGKSTL FNRIIKEKKA IVEDKPGVTR DRMYGNAEWL TLPFIIVDTG
GITLQDTAFA KEIKMQAEIA IKEADVIVFV INFREGITLE DEVVAKILYK TKKPVILAVN
KYDKKQTYDE SYSFMTLGFG EPCLISSTHG IGVGDLLESI TAKMPKFAMN ENSDDIKISI
VGKPNVGKSS LVNSIVGEER MIVSEVAGTT IDSVDTKIKV EGKNYTIIDT AGMRKKGKIY
ENLEKYSYLR SLTSINKADV VILMLDASQP VTDHDTNIGG FAYEENKPII IIGNKWDLVK
NKESNTMKKK EEEIKAYFKY LNYAKVIFIS AKENKRVHKI FEIVELVRDN IKKRIRTSLL
NEIFNKAQLI NPAPNHNGGR LKIYYASQVE AYLPTFVLFV NNPSFVHFSY KRFLENQIRS
QFDFSGVPIN IIFRERK
//
