ID V5WIL7_9SPIO Unreviewed; 451 AA.
AC V5WIL7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN ORFNames=L21SP2_2103 {ECO:0000313|EMBL:AHC15470.1};
OS Salinispira pacifica.
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Spirochaetaceae;
OC Salinispira.
OX NCBI_TaxID=1307761 {ECO:0000313|EMBL:AHC15470.1, ECO:0000313|Proteomes:UP000018680};
RN [1] {ECO:0000313|EMBL:AHC15470.1, ECO:0000313|Proteomes:UP000018680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L21-RPul-D2 {ECO:0000313|EMBL:AHC15470.1,
RC ECO:0000313|Proteomes:UP000018680};
RX PubMed=26203324; DOI=10.1186/1944-3277-10-7;
RA Ben Hania W., Joseph M., Schumann P., Bunk B., Fiebig A., Sproer C.,
RA Klenk H.P., Fardeau M.L., Spring S.;
RT "Complete genome sequence and description of Salinispira pacifica gen.
RT nov., sp. nov., a novel spirochaete isolated form a hypersaline microbial
RT mat.";
RL Stand. Genomic Sci. 10:7-7(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
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DR EMBL; CP006939; AHC15470.1; -; Genomic_DNA.
DR RefSeq; WP_024268376.1; NC_023035.1.
DR AlphaFoldDB; V5WIL7; -.
DR STRING; 1307761.L21SP2_2103; -.
DR KEGG; slr:L21SP2_2103; -.
DR PATRIC; fig|1307761.3.peg.2096; -.
DR eggNOG; COG0372; Bacteria.
DR HOGENOM; CLU_025068_2_2_12; -.
DR OrthoDB; 9800864at2; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000018680; Chromosome.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:AHC15470.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018680};
KW Transferase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000313|EMBL:AHC15470.1}.
FT ACT_SITE 326
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 387
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 451 AA; 50570 MW; EDEF29BF265F9389 CRC64;
MNEAQFLDDH AVLIETPQVI DASEYQKYSV KRGLRNEDGT GVLVGLTEIG DVHGYILDEN
EKIPVEGRLR YRGINIKDIV DNFQSEGRFG FEEVIYLLLF GRLPSRTQHE DFTKLIGGRR
TMPPGYWEDI ILRSPSPDIM NKLGMATLGT YSYDDNPEEN SIRNVLRQSI ELIARFPAMV
AYSYQAKRRF YNNESLIIHA QNPGFSTAEN FLHMIRPTGE YTPLEAELLD LALVLHAEHG
GGNNSAFTVH VVTSAYTDTY SAIAAAVGSL KGSRHGGASN RVREMVNNIK DNVQDWSNRK
EVLGYLKKIL QGKAHDGSGL IYGMGHAIYT ASDPRAVLLK EKAKSLAENV GGRIQEEYGL
YELIQELSPK AFAEVKHNEK VISPNVDFYS GFVYSMLGIP EELFTPIFAV SRIAGWCAHR
LEELSLGSRI YRPAYKNVLG ARPFIPMGER E
//
