ID V5X6L0_MYCNE Unreviewed; 382 AA.
AC V5X6L0;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Uroporphyrinogen III synthetase {ECO:0000313|EMBL:AHC23647.1};
DE EC=4.2.1.75 {ECO:0000313|EMBL:AHC23647.1};
GN ORFNames=D174_03150 {ECO:0000313|EMBL:AHC23647.1};
OS Mycolicibacterium neoaurum VKM Ac-1815D.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=700508 {ECO:0000313|EMBL:AHC23647.1, ECO:0000313|Proteomes:UP000018763};
RN [1] {ECO:0000313|EMBL:AHC23647.1, ECO:0000313|Proteomes:UP000018763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-1815D {ECO:0000313|EMBL:AHC23647.1,
RC ECO:0000313|Proteomes:UP000018763};
RX PubMed=24435872;
RA Shtratnikova V.Y., Bragin E.Y., Dovbnya D.V., Pekov Y.A., Schelkunov M.I.,
RA Strizhov N., Ivashina T.V., Ashapkin V.V., Donova M.V.;
RT "Complete Genome Sequence of Sterol-Transforming Mycobacterium neoaurum
RT Strain VKM Ac-1815D.";
RL Genome Announc. 2:e01177-13(2014).
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DR EMBL; CP006936; AHC23647.1; -; Genomic_DNA.
DR RefSeq; WP_019511711.1; NC_023036.2.
DR AlphaFoldDB; V5X6L0; -.
DR KEGG; mne:D174_03150; -.
DR eggNOG; COG1587; Bacteria.
DR eggNOG; COG3710; Bacteria.
DR HOGENOM; CLU_011276_9_1_11; -.
DR Proteomes; UP000018763; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR039793; UROS/Hem4.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW Lyase {ECO:0000313|EMBL:AHC23647.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018763}.
FT DOMAIN 281..374
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 281..374
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 382 AA; 40733 MW; 7BC1B9D1196607DA CRC64;
MTGPDWAPLT GFRVAVTSAR RSEELAALLT RRGADVTSAA AITMVPLPDD DELRTNTEAL
IAAPPNIVIA TTGIGFRGWI AAADGWGLAH DLTAALGNAR IVSRGPKATG ALRAAGLPEE
WSPESESSRE LLHYLLEGGI VGMRVAVQLH GTNDDWDPFP EFLDELRAAG ADVVPIRVYR
WNPAPRNGPF DQLVLSIADQ RFDAVSFTSA PAVAALLLRA ADLGVESAVL DALRTNVHAM
CVGPITARPL VRLGVPTSAP ERMRLGALAR HITDELPLLQ SRRMRVAGHL LEIRGTCVLV
DDVVKELPPA GMATIRALAH RPGSVVSRQD LLNALPGSGT DTHAVETAVL RLRNALGDKN
IVSTVVKRGY RLAVDEYPMG VS
//
