ID V5XCA9_MYCNE Unreviewed; 506 AA.
AC V5XCA9;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Choline dehydrogenase {ECO:0000313|EMBL:AHC26050.1};
GN ORFNames=D174_16310 {ECO:0000313|EMBL:AHC26050.1};
OS Mycolicibacterium neoaurum VKM Ac-1815D.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=700508 {ECO:0000313|EMBL:AHC26050.1, ECO:0000313|Proteomes:UP000018763};
RN [1] {ECO:0000313|EMBL:AHC26050.1, ECO:0000313|Proteomes:UP000018763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-1815D {ECO:0000313|EMBL:AHC26050.1,
RC ECO:0000313|Proteomes:UP000018763};
RX PubMed=24435872;
RA Shtratnikova V.Y., Bragin E.Y., Dovbnya D.V., Pekov Y.A., Schelkunov M.I.,
RA Strizhov N., Ivashina T.V., Ashapkin V.V., Donova M.V.;
RT "Complete Genome Sequence of Sterol-Transforming Mycobacterium neoaurum
RT Strain VKM Ac-1815D.";
RL Genome Announc. 2:e01177-13(2014).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; CP006936; AHC26050.1; -; Genomic_DNA.
DR RefSeq; WP_019509882.1; NC_023036.2.
DR AlphaFoldDB; V5XCA9; -.
DR SMR; V5XCA9; -.
DR KEGG; mne:D174_16310; -.
DR eggNOG; COG2303; Bacteria.
DR HOGENOM; CLU_002865_7_1_11; -.
DR Proteomes; UP000018763; Chromosome.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Reference proteome {ECO:0000313|Proteomes:UP000018763}.
FT DOMAIN 253..267
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 95..98
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 222
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 506 AA; 53410 MW; DE5E6D38DB459ADC CRC64;
MNAGASDAEV FDHIVVGAGS AGCVIAARLA AAGARVGLLE AGGTDRRPDV RLPLGIASLF
ATANWRYPML PDPSKHDQPG AFAAGRIIGG SGSINAMVYV RGRAADYRRW ALAGATGWDH
EDVLPAFRAL ENWCDGADEF RGSGGPIDVS WCGHTHPLDA AFLDAAAESG FDRNPDHNGA
SQLGAGPAQV NQRRGLRCSA ATGFLRALPA DRRPRVITRA PVDRVVLERG RAIGVMTRGR
LLRAEHDVIL SAGAIGTPAV LLRSGIGPGG TAADLSGVGQ NLQDHLVVAQ HWSSHVPTIN
SLTAPQAARA LGSLAARGSG PLTTTPFEAQ LFTDDFQIAI SPIHYQLDPL RGRARIGRAD
AFTVYTVLLH PRSRGHVELR NGKPVVRHHR LADAQDRADL LSGAALAREL VESTSAMRPM
AGRYLDDTGD FDADWLGDKE SSIYHAVGTC RMGTDDNAVV GPDLRVHAVD GLRVADASIM
PNITSGNTNA PSMMIGYRAA DVILHG
//
