ID V5XEC6_MYCNE Unreviewed; 528 AA.
AC V5XEC6;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Major facilitator transporter {ECO:0000313|EMBL:AHC26031.1};
GN ORFNames=D174_16180 {ECO:0000313|EMBL:AHC26031.1};
OS Mycolicibacterium neoaurum VKM Ac-1815D.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=700508 {ECO:0000313|EMBL:AHC26031.1, ECO:0000313|Proteomes:UP000018763};
RN [1] {ECO:0000313|EMBL:AHC26031.1, ECO:0000313|Proteomes:UP000018763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-1815D {ECO:0000313|EMBL:AHC26031.1,
RC ECO:0000313|Proteomes:UP000018763};
RX PubMed=24435872;
RA Shtratnikova V.Y., Bragin E.Y., Dovbnya D.V., Pekov Y.A., Schelkunov M.I.,
RA Strizhov N., Ivashina T.V., Ashapkin V.V., Donova M.V.;
RT "Complete Genome Sequence of Sterol-Transforming Mycobacterium neoaurum
RT Strain VKM Ac-1815D.";
RL Genome Announc. 2:e01177-13(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP006936; AHC26031.1; -; Genomic_DNA.
DR RefSeq; WP_019509908.1; NC_023036.2.
DR AlphaFoldDB; V5XEC6; -.
DR KEGG; mne:D174_16180; -.
DR eggNOG; COG0477; Bacteria.
DR HOGENOM; CLU_034180_11_1_11; -.
DR Proteomes; UP000018763; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd06173; MFS_MefA_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR010290; TM_effector.
DR PANTHER; PTHR23513; INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED; 1.
DR PANTHER; PTHR23513:SF11; STAPHYLOFERRIN A TRANSPORTER; 1.
DR Pfam; PF05977; MFS_3; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018763};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..402
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 528 AA; 56054 MW; 0A815E729DCEF12C CRC64;
MSSPVTTWAP LRSPVFRALW IAQFVSNLGT WMQMVGAQWM LVGDPRAAVL VPLVQTATTL
PVMLLALPSG VLADLIDRRR LLIATQGAMA SAVALLAVLT GTGLTTPTVL LLLLFLIGCG
QALTMPAWQA IQPDLVPAAQ IPAAAALGSM SMNGARAIGP AIAGALVSLS GPTVVFALNA
VSFVGTVIVL VLWRRPTVDQ NFPSERALAA LSAGGRYIRS SPIVRRILLR TALFIAPASA
LWGLLPVIAD RKLGLTSSGY GLLLGALGLG AVLGAVGLSR LRSRFGENTL LALAATGFAA
ATAVLALVDL FAVVLIALVF GGTAWLLCLS TLNASMQLSL PGWVRARGLS VYQLIFMGGQ
ALGSILWGVL AGTTTPVNSL LVSAGLLVGC AISTLWWPLH AKTGNIDLSP SSHWPEPSLV
IEPEPLDGPV LVMTDYLVPV QDEEQFLAAM AVLGRSRQRT GAARWRLYRS VEREQTFVET
FIVRSWGEHL HQHHTRQTGQ DLVIEQNVER YAQGKPVSHH LIAVPPQR
//
