ID V5XEJ1_MYCNE Unreviewed; 955 AA.
AC V5XEJ1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:AHC26432.1};
GN ORFNames=D174_18485 {ECO:0000313|EMBL:AHC26432.1};
OS Mycolicibacterium neoaurum VKM Ac-1815D.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=700508 {ECO:0000313|EMBL:AHC26432.1, ECO:0000313|Proteomes:UP000018763};
RN [1] {ECO:0000313|EMBL:AHC26432.1, ECO:0000313|Proteomes:UP000018763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-1815D {ECO:0000313|EMBL:AHC26432.1,
RC ECO:0000313|Proteomes:UP000018763};
RX PubMed=24435872;
RA Shtratnikova V.Y., Bragin E.Y., Dovbnya D.V., Pekov Y.A., Schelkunov M.I.,
RA Strizhov N., Ivashina T.V., Ashapkin V.V., Donova M.V.;
RT "Complete Genome Sequence of Sterol-Transforming Mycobacterium neoaurum
RT Strain VKM Ac-1815D.";
RL Genome Announc. 2:e01177-13(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP006936; AHC26432.1; -; Genomic_DNA.
DR RefSeq; WP_019514654.1; NC_023036.2.
DR AlphaFoldDB; V5XEJ1; -.
DR KEGG; mne:D174_18485; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_3_2_11; -.
DR Proteomes; UP000018763; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018763};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 757..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 782..807
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 813..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..374
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 594..929
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 955 AA; 103371 MW; 9F7B87EFC8A09D91 CRC64;
MSSNRIPDFI RRYSVLIALF WLALAVVTNV FVPQLETVAE QHNVSLSPQD APSLQASKQI
GKVFQEFDSD SSAMIVLEGD QPLGAEAHHY YDDLVAKLSA DTTHVQHIDN FWGDPLTAAG
SQSSDGKAAL VQLYLAGNQG ESLANESVDA VRDIVADSPP PEGLRVYVTG AAPLVTDQFE
VGRHGTLKTT IITLLVIAVM LFWLYRRLTT VFLVIFTVMI ELTASRGVVA VLANAGIIEL
STYSTNLLTL LVIAAGTDYA IFLLGRFHEA RYAGQDRVNA FNTMYHGTAH IILGSGLTIA
GAVLCLTFTR LPYFQSLGVP AGTGVLVAVI AALTLAPALI SIGRHFGLFE PARPMQTRGW
RRIGTAIVRW PGPILAATIA IALIGLLALP QYKTSYDAKP YLPASAPANV GYTAAAQHFS
QARLNPELLM IETDHDLRNP TDMILLERVA KAVFHTDGIA QVQSITRPLG TPLDHTSIPF
QISASSASQI NNLPFQQARG QDLLKQVDVI NNSIDILRQQ YALQQQSSAV TDAQSKAFEQ
TVQTAEDLRD KIANFDDQFR PLRNYFYWEP HCFDIPMCAA IRSLFDALDG VDALTDQLNN
VSGSIAQLDA LQPKLLALIP PQIQSQETNR DLTMTNYATT SGLNDQAAAA LENATALGKA
YDASKTDDSF YLPPEAFTNP EFVRGMKLFM SPDGKAARMI ITHDGDPATP EGISHIDAIR
HAAQEAVKGT PLAGSKIYLA GTAATYKDIQ DGAKYDLMIA AIAALCLILL VMVFITRSIV
AALVIVGTVA LSLGASFGLS VLIWQDILGT ELFWIVLALA IILLLAVGSD YNLLLISRFK
EEIDAGLNTG IIRAMGGSGA VVTAAGLVFA ATMASFVFAD LKILGQIGTT IALGLLFDTL
IVRSFMTPAI AALLGRWFWW PLRVRQRPAS ATMRPRATNQ QLRLWEDDDP VVART
//
