ID V6EYS4_MAGGM Unreviewed; 230 AA.
AC V6EYS4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Ribosomal large subunit pseudouridine synthase C {ECO:0000256|ARBA:ARBA00017128};
DE EC=5.4.99.24 {ECO:0000256|ARBA:ARBA00012785};
DE AltName: Full=23S rRNA pseudouridine(955/2504/2580) synthase {ECO:0000256|ARBA:ARBA00030705};
DE AltName: Full=rRNA pseudouridylate synthase C {ECO:0000256|ARBA:ARBA00031975};
DE AltName: Full=rRNA-uridine isomerase C {ECO:0000256|ARBA:ARBA00033053};
GN OrderedLocusNames=MGMSRv2__0158 {ECO:0000313|EMBL:CDK97373.1};
OS Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271
OS / MSR-1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Magnetospirillum.
OX NCBI_TaxID=431944 {ECO:0000313|EMBL:CDK97373.1, ECO:0000313|Proteomes:UP000018922};
RN [1] {ECO:0000313|EMBL:CDK97373.1, ECO:0000313|Proteomes:UP000018922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1
RC {ECO:0000313|Proteomes:UP000018922};
RX PubMed=24625872; DOI=10.1128/genomeA.00171-14;
RA Wang X., Wang Q., Zhang W., Wang Y., Li L., Wen T., Zhang T., Zhang Y.,
RA Xu J., Hu J., Li S., Liu L., Liu J., Jiang W., Tian J., Li Y., Schuler D.,
RA Wang L., Li J.;
RT "Complete genome sequence of Magnetospirillum gryphiswaldense MSR-1.";
RL Genome Announc. 2:e00171-e00114(2014).
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil at
CC positions 955, 2504 and 2580 in 23S ribosomal RNA.
CC {ECO:0000256|ARBA:ARBA00002876}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine(955/2504/2580) in 23S rRNA =
CC pseudouridine(955/2504/2580) in 23S rRNA; Xref=Rhea:RHEA:42528,
CC Rhea:RHEA-COMP:10099, Rhea:RHEA-COMP:10100, ChEBI:CHEBI:65314,
CC ChEBI:CHEBI:65315; EC=5.4.99.24;
CC Evidence={ECO:0000256|ARBA:ARBA00000381};
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DR EMBL; HG794546; CDK97373.1; -; Genomic_DNA.
DR RefSeq; WP_024078417.1; NZ_CP027526.1.
DR AlphaFoldDB; V6EYS4; -.
DR STRING; 1430440.MGMSRv2__0158; -.
DR KEGG; mgry:MSR1_20410; -.
DR KEGG; mgy:MGMSRv2__0158; -.
DR eggNOG; COG0564; Bacteria.
DR HOGENOM; CLU_016902_11_1_5; -.
DR OrthoDB; 9807829at2; -.
DR Proteomes; UP000018922; Chromosome I.
DR GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF93; PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:CDK97373.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018922}.
FT DOMAIN 17..166
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
SQ SEQUENCE 230 AA; 25395 MW; FE2784744C569315 CRC64;
MSPDELLARV LYRDAMVLII DKPAGLAVHA GARDGSHHLM DLLEPLRFGL PRNPELAHRL
DRDTSGCLVL GRHRKALARL GEIFAGSEAQ KTYWAVVVGK PPAESGIIDK RLKKLERRHG
WRMVVDDKGQ DAVTEYRVLG GNGRLSWIEA KPRTGRTHQI RVHLAAIGCP IVGDSTYGRG
TADLVSPHLH LHARSITLPY NPKKSPITAQ APVPAHMIDA LIQCGWHNQD
//
