ID V6F874_HAPBU Unreviewed; 765 AA.
AC V6F874;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Forkhead box protein P2 {ECO:0000256|ARBA:ARBA00040052};
GN Name=FoxP2 {ECO:0000313|EMBL:DAA64557.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|EMBL:DAA64557.1};
RN [1] {ECO:0000313|EMBL:DAA64557.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24349554;
RA Song X., Wang Y., Tang Y.;
RT "Rapid Diversification of FoxP2 in Teleosts through Gene Duplication in the
RT Teleost-Specific Whole Genome Duplication Event.";
RL PLoS ONE 8:E83858-E83858(2013).
RN [2] {ECO:0000313|Ensembl:ENSHBUP00000004249.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; BK008620; DAA64557.1; -; mRNA.
DR RefSeq; NP_001302467.1; NM_001315538.1.
DR STRING; 8153.ENSHBUP00000004249; -.
DR Ensembl; ENSHBUT00000009017.1; ENSHBUP00000004249.1; ENSHBUG00000005609.1.
DR GeneID; 102293528; -.
DR CTD; 93986; -.
DR GeneTree; ENSGT00940000155480; -.
DR OMA; XHLNNEH; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR CDD; cd20065; FH_FOXP2; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047412; FH_FOXP1_P2.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032354; FOXP-CC.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR PANTHER; PTHR45796:SF1; FORKHEAD BOX PROTEIN P2; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16159; FOXP-CC; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 506..579
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 506..579
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 83085 MW; 9B7808A2B1F9D3B7 CRC64;
MMQESATETI SNSSMSQNGM STLSSSQLEA GSRDGRSSAG DTSSEVSTVE LLHLQQQQAL
QAARQLLLQQ PGSGLKSPKS QDKQRPLQVP VSVAMMSPQV MTPQQMQQIL QQQVLSPQQL
QALLQQQQAV MLQQQHLQEF YKKQQEQLHL QLLQQQHPGK QVKEQQQQQQ QLAAQQLVFQ
QQLLQMQQLQ QQQHLLNMQR QGLLTLPGPA PGQAALPGQT LPPPAGLSPA ELQQLWKDVT
GGGGHGMEDN GIKHSSGTGT GVGGGGGLDL STNNSSSTTS SSNPAKASPP ISHHSIANGQ
SPALNHRRER ERERERERES SLHEESGGTH PLYGHGVCKW PGCENICEDF GQFLKHLNSE
HALDDRSTAQ CRVQMQVVQQ LEIQLSKERE RLQAMMTHLH MRPSEPKSSP KPLNLVSSVT
MSKNLPSASP PNLPQTPTTP TAPITPMAAM PHVPSVLGGA NVPSMGAMRR RHSDKYSMPL
SSGGDTVFIF PEIAPNYEFY KNADVRPPFT YATLIRQAIM DSADMQLTLN EIYSWFTRTF
AYFRRNAATW KNAVRHNLSL HKCFVRVENV KGAVWTVDEV EYQKRRSQKI TGSPSLVKNL
PSSLGYGTAL NASLQAALAE TSLPLLGTPG LMGSGATGPM GGTCHGLLGG DPSGLTAGSP
PGQLGGSPPG LLGVSPPVTL SGSPPMLLQS AHEDLNGSVD HLDTNGHSSP RYSPPVHMPP
IHIKEEPLNM DDDDCPMSLV TTANHSPELE EDRELEEGNL SEDLE
//
