ID V6HV02_9LEPT Unreviewed; 753 AA.
AC V6HV02;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=NeuB family protein {ECO:0000313|EMBL:EQA61156.1};
GN ORFNames=LEP1GSC062_1374 {ECO:0000313|EMBL:EQA61156.1};
OS Leptospira alexanderi serovar Manhao 3 str. L 60.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1049759 {ECO:0000313|EMBL:EQA61156.1, ECO:0000313|Proteomes:UP000018747};
RN [1] {ECO:0000313|EMBL:EQA61156.1, ECO:0000313|Proteomes:UP000018747}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L 60 {ECO:0000313|EMBL:EQA61156.1,
RC ECO:0000313|Proteomes:UP000018747};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Hartskeerl R.A., Ahmed A.,
RA van der Linden H., Goris M.G.A., Vinetz J.M., Sutton G.G., Nierman W.C.,
RA Fouts D.E.;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQA61156.1}.
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DR EMBL; AHMT02000052; EQA61156.1; -; Genomic_DNA.
DR RefSeq; WP_010578359.1; NZ_AHMT02000052.1.
DR AlphaFoldDB; V6HV02; -.
DR STRING; 100053.GCA_002009845_01993; -.
DR OrthoDB; 9814210at2; -.
DR Proteomes; UP000018747; Unassembled WGS sequence.
DR GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR CDD; cd11615; SAF_NeuB_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.90.1210.10; Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR InterPro; IPR006190; AFP_Neu5c_C.
DR InterPro; IPR036732; AFP_Neu5c_C_sf.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR013132; Neu5Ac_N.
DR InterPro; IPR013974; SAF.
DR InterPro; IPR036237; Xyl_isomerase-like_sf.
DR InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR PANTHER; PTHR42966:SF3; BLR5971 PROTEIN; 1.
DR PANTHER; PTHR42966; N-ACETYLNEURAMINATE SYNTHASE; 1.
DR Pfam; PF01261; AP_endonuc_2; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF03102; NeuB; 1.
DR Pfam; PF08666; SAF; 1.
DR SMART; SM00858; SAF; 1.
DR SUPFAM; SSF51269; AFP III-like domain; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF51658; Xylose isomerase-like; 1.
DR PROSITE; PS50844; AFP_LIKE; 1.
DR PROSITE; PS51371; CBS; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}.
FT DOMAIN 3..63
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 407..465
FT /note="AFP-like"
FT /evidence="ECO:0000259|PROSITE:PS50844"
SQ SEQUENCE 753 AA; 86204 MW; F09CBEFBAD00D523 CRC64;
MIIDKNISQY VVFWEDSIKN ALKKIEANKS KTIFAVSEGN KLMGVITDGD FRRWLLNDDV
ADRSLDQEVK NIVNTSFKYL YITESSKRIR STFNNRISII PLINENGVLE AIAKETSEEI
LVEGISLSHG SPAFVIAEIG NNHNGSFELA KKLVREAKLA GADCAKFQMR NLNALYRNSG
NANDVEEDLG SQYTLDLLNK FQLSDDELFR IFDYCREESL IPLCTPWDEE SFFKLEKYGI
SAYKIASADF TNHELVRLVA KSGKPVICST GMSTEDEIID SIHVLQDLGA QYILLHCNST
YPAPFKDLNL RYLQHLKNIG NCLVGYSGHE RGYLVALAAV SLGAKVIEKH FTLDREMEGN
DHKVSLLPSE FREMVDGIRQ IEESLGNGNF RQITQGELMN RETLGKSLLI NRDLKFGEII
TSDMVDIRSP GKGLPPYLKE KLIGKSAKRN FKKGDFFYKS DIVDDVIEFK KKFIFSRPWG
LPVRYHDLEQ ILSKVEMDLV EFHFSYKDLN VEISEYIKKP LNIDFVVHCP ELFENDHLLD
LCTEDEDYRR RSLREIQKVI DITRRLKDFF PNSNKKPFIV TNVGGFSLDK PLDMTIRGKL
YENLVRSLND LDSEGVEIIP QTMPPFPWLF GGQRYHNLFL SAEEIVEFCE RYSVRICLDI
SHSKLACNHY HWPFSKFVEQ VSPYVAHLHI VDAKGVDGEG LQIGEGEIDF HMLSNILKEK
APKASFIPEI WQGHKNNGEG FLISLTRLEK FHL
//
