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Database: UniProt
Entry: V6HWQ1_9LEPT
LinkDB: V6HWQ1_9LEPT
Original site: V6HWQ1_9LEPT 
ID   V6HWQ1_9LEPT            Unreviewed;       704 AA.
AC   V6HWQ1;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   11-DEC-2019, entry version 26.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN   Name=feoB {ECO:0000313|EMBL:EQA62335.1};
GN   ORFNames=LEP1GSC062_3525 {ECO:0000313|EMBL:EQA62335.1};
OS   Leptospira alexanderi serovar Manhao 3 str. L 60.
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=1049759 {ECO:0000313|EMBL:EQA62335.1, ECO:0000313|Proteomes:UP000018747};
RN   [1] {ECO:0000313|EMBL:EQA62335.1, ECO:0000313|Proteomes:UP000018747}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L 60 {ECO:0000313|EMBL:EQA62335.1,
RC   ECO:0000313|Proteomes:UP000018747};
RA   Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA   Sanka R., DePew J., Purushe J., Hartskeerl R.A., Ahmed A.,
RA   van der Linden H., Goris M.G.A., Vinetz J.M., Sutton G.G., Nierman W.C.,
RA   Fouts D.E.;
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EQA62335.1}.
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DR   EMBL; AHMT02000034; EQA62335.1; -; Genomic_DNA.
DR   RefSeq; WP_020984304.1; NZ_AHMT02000034.1.
DR   EnsemblBacteria; EQA62335; EQA62335; LEP1GSC062_3525.
DR   OrthoDB; 304844at2; -.
DR   BioCyc; GCF_000243815:G1EG9-1892-MONOMER; -.
DR   Proteomes; UP000018747; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR006073; GTP_binding_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|RuleBase:RU362098};
KW   Ion transport {ECO:0000256|RuleBase:RU362098};
KW   Iron {ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|RuleBase:RU362098};
KW   Membrane {ECO:0000256|RuleBase:RU362098};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM        290..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        350..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        395..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        429..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        461..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        526..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        649..668
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        680..703
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   DOMAIN          12..175
FT                   /note="FeoB-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51711"
SQ   SEQUENCE   704 AA;  78383 MW;  FB8915508642D318 CRC64;
     MDHSKTVLNP KTSRILMAGN PNCGKSTLFN RLTGLRQKTG NYHGVTVEKA EGLLSHEEQS
     LKVLDLPGAF SLGGNSEDKQ ITSRVLISHQ EGDKILFVMD ASLAERSLQF LLQVLELNVP
     VLVAVTMKDV LEKKRIRLEL DSLSREFGIL FQYVNPKNGD GVQELKDLIF SPDSFRLPIR
     SFSWDPEREK FLNGLLKSFS SEHSDSLKFV LINSFKELSG EVLQKGLPGL SLFPQGSRKF
     IREEFDRFGK RFTYLEELTQ KSIYIKKVLG NAIVGNPIPN ERILSKADKI LLHPFWGVVS
     FLGIMALVFQ ALFTWSEIPM NWIELTVQSV GSFVGRFLDE GPLRSLIQEG IIGGVGAVLV
     FIPQISLLFL FIGILEETGY IARASFVMDR FMGKFGLSGK SFIPLLSSAA CAVPAIMGAR
     TIENKSDRIT TILVAPLITC SARYPVYILV IGAIFPAGNL WGIFNIQALT MLGLFLLGMI
     SSMLAALVFK KTFFKSDSSY FLMELPAYNT PSIKSLALTV FKKLKAFLST AGQIILFISI
     LLWFLANYPR IDSSLYPNAG DAELKKIQIR ESYAGSAGKF MEPVLKPIGF DWKMGIGIIT
     SFAAREIMVS TLSIIYGVGG EESDDDLKEA IRKDKDEDGK AVWGLKNSVS LLLFFAFACQ
     CMSTIAVVKK ETNSFFWPSF LFTYMTILAY SASFSVFQIW SLFS
//
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