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Database: UniProt
Entry: V6J4D5_9BACL
LinkDB: V6J4D5_9BACL
Original site: V6J4D5_9BACL 
ID   V6J4D5_9BACL            Unreviewed;       316 AA.
AC   V6J4D5;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=Thioredoxin reductase {ECO:0000256|ARBA:ARBA00018719, ECO:0000256|RuleBase:RU003880};
DE            EC=1.8.1.9 {ECO:0000256|RuleBase:RU003880};
GN   ORFNames=P343_11470 {ECO:0000313|EMBL:EST11584.1};
OS   Sporolactobacillus laevolacticus DSM 442.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Sporolactobacillaceae;
OC   Sporolactobacillus.
OX   NCBI_TaxID=1395513 {ECO:0000313|EMBL:EST11584.1, ECO:0000313|Proteomes:UP000018296};
RN   [1] {ECO:0000313|EMBL:EST11584.1, ECO:0000313|Proteomes:UP000018296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 442 {ECO:0000313|EMBL:EST11584.1,
RC   ECO:0000313|Proteomes:UP000018296};
RX   PubMed=24371202;
RA   Wang H., Wang L., Ju J., Yu B., Ma Y.;
RT   "Genome Sequence of Sporolactobacillus laevolacticus DSM442, an Efficient
RT   Polymer-Grade D-Lactate Producer from Agricultural Waste Cottonseed as a
RT   Nitrogen Source.";
RL   Genome Announc. 1:e01100-13(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide +
CC         H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC         COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9;
CC         Evidence={ECO:0000256|ARBA:ARBA00000849,
CC         ECO:0000256|RuleBase:RU003880};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|RuleBase:RU003881};
CC       Note=Binds 1 FAD per subunit. {ECO:0000256|RuleBase:RU003881};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738,
CC       ECO:0000256|RuleBase:RU003880}.
CC   -!- SIMILARITY: Belongs to the class-II pyridine nucleotide-disulfide
CC       oxidoreductase family. {ECO:0000256|ARBA:ARBA00009333,
CC       ECO:0000256|RuleBase:RU003880}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EST11584.1}.
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DR   EMBL; AWTC01000010; EST11584.1; -; Genomic_DNA.
DR   RefSeq; WP_023510540.1; NZ_AWTC01000010.1.
DR   AlphaFoldDB; V6J4D5; -.
DR   STRING; 1395513.P343_11470; -.
DR   PATRIC; fig|1395513.3.peg.2317; -.
DR   eggNOG; COG0492; Bacteria.
DR   OrthoDB; 9806179at2; -.
DR   Proteomes; UP000018296; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004791; F:thioredoxin-disulfide reductase (NADP) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019430; P:removal of superoxide radicals; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR008255; Pyr_nucl-diS_OxRdtase_2_AS.
DR   InterPro; IPR005982; Thioredox_Rdtase.
DR   NCBIfam; TIGR01292; TRX_reduct; 1.
DR   PANTHER; PTHR48105:SF16; THIOREDOXIN REDUCTASE 1-RELATED; 1.
DR   PANTHER; PTHR48105; THIOREDOXIN REDUCTASE 1-RELATED-RELATED; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00368; FADPNR.
DR   PRINTS; PR00469; PNDRDTASEII.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS00573; PYRIDINE_REDOX_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   FAD {ECO:0000256|RuleBase:RU003880};
KW   Flavoprotein {ECO:0000256|RuleBase:RU003880};
KW   NADP {ECO:0000256|RuleBase:RU003881};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003880};
KW   Redox-active center {ECO:0000256|ARBA:ARBA00023284,
KW   ECO:0000256|RuleBase:RU003880};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018296}.
FT   DOMAIN          8..295
FT                   /note="FAD/NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF07992"
SQ   SEQUENCE   316 AA;  34360 MW;  70E6370121FBF7B6 CRC64;
     MAEQEKIYDV IIAGAGPAGM TAAVYAARAN MSVLMIERGI PGGQMANTEA VENYPGFESI
     LGPDLSNKMF EHAKKFGAEY AYGDIKKIVD GPDFKTIDCG SKQYKARTVI VTTGAEYRKL
     GVPGEKEFAG RGVSYCAVCD GAFFKEKKLT VIGGGDSAVE EGTYLTRFAS KVTIIHRRDQ
     LRAQKILQNR AFNNEKVDFI WDTICTKING KDGKVSSLTL QNKKTGEETD FPADGVFIYV
     GMDPLTNAVK DLGIVDEQGY IVTNEKMETS IPGIFAAGDV RQKELRQIVT ATGDGSIAAE
     NAQKYVEKIK DASEVK
//
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