UniProt: V6JIL5

Database: UniProt
Entry: V6JIL5_STRNV

LinkDB:  V6JIL5_STRNV 
Original site:  V6JIL5_STRNV

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Ontology (4)   
   GO (4)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (40)   
   InterPro (21)   
   Pfam (9)   
   PROSITE (4)   
   SMART (6)   
Literature (1)   
   PubMed (1)   
All databases (47)   

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ID   V6JIL5_STRNV            Unreviewed;      3196 AA.
AC   V6JIL5;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EST19568.1};
DE   Flags: Fragment;
GN   ORFNames=M877_35985 {ECO:0000313|EMBL:EST19568.1};
OS   Streptomyces niveus NCIMB 11891.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1352941 {ECO:0000313|EMBL:EST19568.1, ECO:0000313|Proteomes:UP000017971};
RN   [1] {ECO:0000313|EMBL:EST19568.1, ECO:0000313|Proteomes:UP000017971}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCIMB 11891 {ECO:0000313|EMBL:EST19568.1,
RC   ECO:0000313|Proteomes:UP000017971};
RX   PubMed=24407644;
RA   Flinspach K., Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT   "Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the
RT   Aminocoumarin Antibiotic Novobiocin.";
RL   Genome Announc. 2:e01146-e01113(2014).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EST19568.1}.
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DR   EMBL; AWQW01000290; EST19568.1; -; Genomic_DNA.
DR   RefSeq; WP_023543227.1; NZ_CM002280.1.
DR   PATRIC; fig|1352941.4.peg.7291; -.
DR   eggNOG; COG3321; Bacteria.
DR   HOGENOM; CLU_000022_35_8_11; -.
DR   OrthoDB; 9778690at2; -.
DR   Proteomes; UP000017971; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 2.
DR   CDD; cd00833; PKS; 2.
DR   Gene3D; 3.30.70.3290; -; 2.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF00698; Acyl_transf_1; 2.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 2.
DR   Pfam; PF00109; ketoacyl-synt; 2.
DR   Pfam; PF02801; Ketoacyl-synt_C; 2.
DR   Pfam; PF08659; KR; 2.
DR   Pfam; PF21089; PKS_DH_N; 2.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF14765; PS-DH; 2.
DR   SMART; SM00827; PKS_AT; 2.
DR   SMART; SM00826; PKS_DH; 2.
DR   SMART; SM00822; PKS_KR; 2.
DR   SMART; SM00825; PKS_KS; 2.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM01294; PKS_PP_betabranch; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00606; KS3_1; 2.
DR   PROSITE; PS52004; KS3_2; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          37..447
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1580..1655
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1673..2085
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   REGION          449..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3175..3196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..470
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         3196
FT                   /evidence="ECO:0000313|EMBL:EST19568.1"
SQ   SEQUENCE   3196 AA;  335828 MW;  AC4249D7CF97C409 CRC64;
     MNAEVEEIVE ALRGSLVENE RLRQDNDSLR AAASVTTEPI AIIGMACRYP GGVGSPEELW
     ALVEEGRDAI SPFPDDRGWD MSALYDPEPG KPGKTYAREG GFLHDAAQFD PEFFGISPRE
     ALTMDPQQRL LLEITWESME RAGLDPASLR GSRTGVFAGA MYHDYGITSS DGSLVSGRVA
     YTLGLEGPAV TVDTACSSSL VALQWASQAL RSGECTLALA GGVSVMATPE TFIEFSEQRG
     LSADGRCRSF AASADGTGWA EGAGVLLLEK LSDARRNGHP VLAVVRGSAV NQDGASNGFS
     APNGPSQRRV IQQALTAAGL TTADVDVMEG HGTGTSLGDP IEAQALLATY GQGREEPLWL
     GSIKSNIGHT QAAAGVAGVI KMVEAIRRGT LPKTLHVDEA SPQVDWEAGN VRLLTEARAW
     PDADRPRRAA VSSFGVSGTN AHVIIEQAQP DPASDSEPEP AAPRPSTDVP LPLPLSAGTE
     TAMRAQARQL ADHLRTTPDL DPVDMAYSLA TARAALTRRA VVVGHDRDEI LGALTALADG
     APLGGAARST GLTAFLFTGQ GSQRLGMGRD LHAAFPVFAR AFDEVCSALD PAVREVMWGD
     EEALRRTEFT QPAIFALQIA LFRLLESWGV RPDFVAGHSI GELAAAHVAG VFSLPDAASL
     ITARARLMQA LPPGGAMVAV EAAEEEVVPL LRDGVGIAAV NGPTSVVLSG TEEAVNAVVE
     QLGARRTNRL KVSHAFHSTL MDPMLDDFRR VAERVAYTEP GIPVVANGDV TTAAYWVGHV
     RDTVRFADAV TRLESEGVTR YVELGPDGIL TAMARQCLTT TADTAVLVPA LRRNETGPVA
     VLTALGGLHT AGLKVDWAGV FDGRGARRVD LPTYPFQRAR YWFDKRGLGG DVTSAGLDRP
     GHPLLGAMVH LPGSDGVVFT GRLSTGAHPW LSDHTVMGSV LLPGTAYVEL AVRAGDQVGW
     NRVEELNVAA PLFLPDHGGV HIQVAVDAPD ASGLRPVRVF SRADDAPLDR EWILHAEGFL
     APDAGEPATD LTVWPPRDAE PLAVEGLYER LEYGPTFQGL RAGWRRGDEL FAETALPEGA
     DADGFGLHPA LFDAALHVLD LAGEDAKVLP FTWSDVTLHA EGATTARVRL RVRGDKSVSL
     ELADAMGRPV ASVGSLTLRP VTADGLAPAA ARVANALFRV DWVPAGEVRS PAENTEVSVH
     HCPPTTGGTP AAVRAVTTGV LAAVQAAVDG GTALVVVTDG ATDGSDLGHA AAWGLVRAAE
     GEHPGRFFLV DTDAPVDPAR VVAIGEPELR VSGGETRVPR LVGVPLESTA STWDTERTVL
     ITGGTGALGA AVARHLVTRH AVRRLLLTSR RGPQAPGAAE LAEELTGLGA EVEVAACDAA
     DRDALATLLD GRTIGGVVHA AGVLDDGVIL SMTPERVDHV LRPKADAAWH LHELTRDMGL
     TAFVLFSSVA GVLGAPGQGN YAAASTLLDG LARHRHAAGL PALSLAWGPW AGEGMADGLA
     SVGMRSLAPE EGLALLDAAA GVAEPVLVPV RFDLAAFDSP PPIMRGLVRG RSRRVLDNDA
     SATGVLRKRL AGLGDAERAD ELLALVRSQA AMVLRHAGAE AVDPERAFRD LGFDSLTAIE
     LRNLLGAATG LRLPATLVFD YPTPVVLAGH LLQELSGAVE SAPVASFVRP EDDEPIAIVS
     MACRYPGGVD TPEDLWRLVD EGVDAISEFP ADRGWGVEDI YDPEPGVPGK TYVRDGGFLH
     DAAQFDAEFF GISPREALDM DPQQRLLLET SWEALERAGI APTTLKGSPT GVFAGVMYHD
     YPGGTGGGSL VSGRVAYTLG LEGPAVSVDT ACSSSLVALH WAAQALRSGE CSLALVGGVT
     VMGTPRSFID FSEQRGLAAD GRCKSFSSST DGTGWGEGAG VLVVERLSEA RRLGHPVLAV
     VRGSALNQDG ASNGITAPNG PSQRRVIKQA LANAGLVAAD VDAVEAHGTG TTLGDPIEAQ
     ALLETYGQDR PEGRPLWLGS IKSNIGHTQA AAGVAGIIKM VEAMRHGRLP MTLHVDEPTK
     QVDWDAGDVR LLTEARDWPS EDRPRRAAIS SFGISGTNAH VIVEEVVPVA EVAVERRELP
     VAPVVVSGKT PAALEAQIGR FGELLREADA LDVAYSAATG RAALEHRAVL IGSETVTGET
     GAGKVAFLFT GQGSQRLGMG RELYETFPVF AVAFDEVCGV LDPAVREVMW GDEEALSRTE
     FTQPAIFALE VALFRLVESW GVRPDFLVGH SIGELAAAHV AGVFGLEDAG RLISARGRLM
     QVLPAGGAMV AIQATEEEVS PLLTEGVSVA AVNSPSSVVI SGEEAAVAAV VERFSDRKRN
     RLTVSHAFHS PLMDPMLDDF RKVAESVTYQ EPVIRLVRDM ASAEYWVRHV RDAVRFADDV
     RHLQDEGVTR FLEIGPDGVL TAMAGQSAEG TLAATLRRDR PEVESVFAGV GRLFAAGVAV
     DWDAVFDGRG ARRVDLPTYP FQRKRYWLIE QSKTTAGADA VDHPLLTSGI VLPDTGGVVF
     TGRLSLDTHP WLADHDVLGT LLLPGTGLVE LALQAAAQVD CGTVDELTLE APLVVPEKGA
     VAVRVLVGGP DDSESRTVEI YSSLDDEIWT RNAAGALLPS AVSPSSDLIQ WPPIGATPLP
     VDGAYERLLA RGYDYGPTFQ GLKAAWRDGD GVVFAEVSLP EGTEAARFGL HPALLDAAMH
     VGLIEEGAAT DAPELPFSWN GVTLHRAGAS ALRVRLSNPE GGDGTDVLVA DGTGAPVLSV
     ASLTSRPVSA EQLRADGDHR ESLFALTWTK AGEVPVLETP VVVYEVPRAE GDTSEAAHAV
     ADEVLARVQE WLADKGRSDE KLAVVTRRAV PIEGEDVDLS QAPVWGLVRA AAAENPGRFL
     LLDLGDGATV PPFVDAPEVV VRGGELLVPA LTRVPASAVD AGRDPWESSP TVLITGGTSG
     LGALVARHLV TEHGIRHLVL TSRRGGSAPG AAELRAELTG HGARVDIEAC DVADRAALAA
     VLDRHPVGAV VHAAGVVDNG LVRGLTPERM DTVLRPKVDG AWHLHELTAD RDLSAFVLFS
     SMGGLLLAAG QGNYAAANVF LDALAHHRHQ AGLPVTSLAF GLWEAETGLG ELTDADRKRM
     LRMGLPALSQ EEGLALLDDA LRTGEPALAP FRLDTGALRT RAVDQLPPLL RGLVPTSRRR
     AGGAGAVGGG DGGAGL
//

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