ID V6JIY9_STRNV Unreviewed; 1010 AA.
AC V6JIY9;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:EST19815.1};
GN ORFNames=M877_35365 {ECO:0000313|EMBL:EST19815.1};
OS Streptomyces niveus NCIMB 11891.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352941 {ECO:0000313|EMBL:EST19815.1, ECO:0000313|Proteomes:UP000017971};
RN [1] {ECO:0000313|EMBL:EST19815.1, ECO:0000313|Proteomes:UP000017971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCIMB 11891 {ECO:0000313|EMBL:EST19815.1,
RC ECO:0000313|Proteomes:UP000017971};
RX PubMed=24407644;
RA Flinspach K., Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the
RT Aminocoumarin Antibiotic Novobiocin.";
RL Genome Announc. 2:e01146-e01113(2014).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST19815.1}.
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DR EMBL; AWQW01000282; EST19815.1; -; Genomic_DNA.
DR RefSeq; WP_023543109.1; NZ_CM002280.1.
DR AlphaFoldDB; V6JIY9; -.
DR PATRIC; fig|1352941.4.peg.7169; -.
DR eggNOG; COG0383; Bacteria.
DR HOGENOM; CLU_003442_0_1_11; -.
DR OrthoDB; 9772207at2; -.
DR Proteomes; UP000017971; Chromosome.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR Gene3D; 2.60.40.2220; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 520..598
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
FT REGION 635..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1010 AA; 110265 MW; 0DC356CC9BF88952 CRC64;
MHDDRKLVEA RLERVLRERI RPAVHPVTTP LSVEIWSTAG EPVPVAEGLA APTTPITPGT
PWGLPWGTSW FTVTGTVPAE WAGRTVEAVL DLGFTPRTPG FQCEGLVYRP DGTPVKGLHP
RNAYVRVGSP VTGGEKVHWR IEAASNPDLD GSGVPFQPTP MGEKATAGQA PQYVLGELRL
AVFDETVWNL VMDLEVLGEL MAELPVDGAR RWDILRAVGR ALDAVDLRDV NGTAQAARDE
LAGVLAAPAV PAAHRISAVG HAHIDSAWLW PLRETVRKVA RTASNMTALL DDDPDFVFAM
SQAQQYAWIK EHRPEVYARV KKAVADGRFV PTGGMWVESD TNMPGSEAMA RQFVHGKRFF
LDEFGIENDE AWLPDTFGFA AGLPQIIKAA GATRLLTQKI SWSRTNTFPH HTFSWEGIDG
TRIFTHFPPV DSYNCEMTGR QIAHAARNFK EKGVATRSLA PTGYGDGGGG TTREMVAKAA
RMRSLEGAAV VEWETPADFF AKAEAEYPDP PVWVGELYLE LHRATLTSQA GTKRGNRRGE
SLLHEAELWA ATAAARTGMP YPYEELDRIW KTVLLHQFHD ILPGSSIAWV HREARETYAR
VAEELETIIA GAQRALAGDT SGGIELVFNS APHARSSAPA GGASTQRTDN GAVIPAPREG
GGYLLDNGLL RVEIDARGLV VSAYDRIADR EAIAPGQAGN LLQLHPDFPN QWDAWDVDAF
YRNVGSDLTE VTELRAEGTS VRVERVFGAS RVTQLLSVPA DAKRLDIDTE VDWHESERFL
KLAFPLDVKA DRYASETQFG HVYRPTHQNT SWEWAKFEAC NHRFVHVDEP GWGVALVNDA
TYGHDVTRAV RTGADAGTTT TVRASLLRAP RYPDPETDQG RHRFRHALAP GATIGDAVRE
GHRVNLPERR VTGSAAEVAP LVSVDNDAVV VSAVKLADDR SGDLVVRLYE AHGGRARATV
LVDGFATDRA VLTDLLERPL ADAESPTAAD GGVVLALRPF QLVTLRLPRA
//
