ID V6JJ24_STRNV Unreviewed; 760 AA.
AC V6JJ24;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Mannose-1-phosphate guanyltransferase {ECO:0000313|EMBL:EST19902.1};
GN ORFNames=M877_35110 {ECO:0000313|EMBL:EST19902.1};
OS Streptomyces niveus NCIMB 11891.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352941 {ECO:0000313|EMBL:EST19902.1, ECO:0000313|Proteomes:UP000017971};
RN [1] {ECO:0000313|EMBL:EST19902.1, ECO:0000313|Proteomes:UP000017971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCIMB 11891 {ECO:0000313|EMBL:EST19902.1,
RC ECO:0000313|Proteomes:UP000017971};
RX PubMed=24407644;
RA Flinspach K., Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the
RT Aminocoumarin Antibiotic Novobiocin.";
RL Genome Announc. 2:e01146-e01113(2014).
CC -!- SIMILARITY: Belongs to the phosphohexose mutase family.
CC {ECO:0000256|ARBA:ARBA00010231}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST19902.1}.
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DR EMBL; AWQW01000278; EST19902.1; -; Genomic_DNA.
DR AlphaFoldDB; V6JJ24; -.
DR STRING; 193462.BBN63_29810; -.
DR PATRIC; fig|1352941.4.peg.7116; -.
DR eggNOG; COG1109; Bacteria.
DR eggNOG; COG1208; Bacteria.
DR HOGENOM; CLU_017652_1_0_11; -.
DR Proteomes; UP000017971; Chromosome.
DR GO; GO:0016868; F:intramolecular phosphotransferase activity; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd05805; MPG1_transferase; 1.
DR CDD; cd04181; NTP_transferase; 1.
DR Gene3D; 3.40.120.10; Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3; 3.
DR Gene3D; 3.30.310.50; Alpha-D-phosphohexomutase, C-terminal domain; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR005844; A-D-PHexomutase_a/b/a-I.
DR InterPro; IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
DR InterPro; IPR005845; A-D-PHexomutase_a/b/a-II.
DR InterPro; IPR005846; A-D-PHexomutase_a/b/a-III.
DR InterPro; IPR036900; A-D-PHexomutase_C_sf.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR PANTHER; PTHR22572:SF15; MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA; 1.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR Pfam; PF02878; PGM_PMM_I; 1.
DR Pfam; PF02879; PGM_PMM_II; 1.
DR Pfam; PF02880; PGM_PMM_III; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF55957; Phosphoglucomutase, C-terminal domain; 1.
DR SUPFAM; SSF53738; Phosphoglucomutase, first 3 domains; 2.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EST19902.1}.
FT DOMAIN 2..162
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 313..439
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02878"
FT DOMAIN 461..561
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02879"
FT DOMAIN 569..669
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02880"
SQ SEQUENCE 760 AA; 81966 MW; 35A8672518FB8410 CRC64;
MELTYANEEK PLGTAGSVKN AEEALKDDAF LVISGDALTD FDLTDLIAFH KEKGALVTVC
LTRVPNPLEF GITIVDEEGK VERFLEKPTW GQVFSDTVNT GIYVMEPEVF DYVEADTSVD
WSGDVFPQLM KEGKPIYGYI AEGYWEDVGT HESYVKAQAD VLEGKVDVDL DGFEISPGVW
VAEGAEVHPD AVLRGPLYIG DYAKVEADAE IREHTVIGSN VVVKTGAFLH RAVVHDNVYI
GQHSNLRGCV IGKNTDIMRA SRIEDGAVIG DECLVGEESI IQGNVRVYPF KTIEAGAFVN
TSVIWESRGQ AHLFGARGVS GILNVEITPE LAVRLAGAYA TTLKKGSTVT TARDHSRGAR
ALKRAVISAL QASAIDVRDL ENVPLPVARQ QTGRGSAGGI MIRTTPGVPD SVDIMFFDER
GADLSQGGQR KLDRVYARQE YRRAFPGEIG DLHFPASVFD SYTGSLLRNV DTSGISEAGL
KVVVDASNGS AGLVLPSLLG RLGVDALTIN PGLDEARPTE TVESRRSGLV RLGEIVASAR
ASFGVRFDPV GERLSLVDER GRIIEDDRAL LVLLDLVAAE RRSGRVALPV TTTRIAEQVA
AYHGTQVEWT TTSPDDLTRV GREDSTIFGG DGRGAFIVPE FSSLLDGTAA FVRLLGLVAR
TQLTLSQIDA RIPRAHVLRR DLATPWAVKG LVMRRVVEAA GDRDVDTTDG VRVVEADGRW
VMVLPAPAEA VTHLWAEGPD DASAQALLDE WAAVVDSAGQ
//
