ID V6JKE6_STRNV Unreviewed; 406 AA.
AC V6JKE6;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Methyltransferase {ECO:0000313|EMBL:EST20392.1};
GN ORFNames=M877_34285 {ECO:0000313|EMBL:EST20392.1};
OS Streptomyces niveus NCIMB 11891.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352941 {ECO:0000313|EMBL:EST20392.1, ECO:0000313|Proteomes:UP000017971};
RN [1] {ECO:0000313|EMBL:EST20392.1, ECO:0000313|Proteomes:UP000017971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCIMB 11891 {ECO:0000313|EMBL:EST20392.1,
RC ECO:0000313|Proteomes:UP000017971};
RX PubMed=24407644;
RA Flinspach K., Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the
RT Aminocoumarin Antibiotic Novobiocin.";
RL Genome Announc. 2:e01146-e01113(2014).
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST20392.1}.
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DR EMBL; AWQW01000267; EST20392.1; -; Genomic_DNA.
DR RefSeq; WP_023542910.1; NZ_CM002280.1.
DR AlphaFoldDB; V6JKE6; -.
DR STRING; 193462.BBN63_28945; -.
DR PATRIC; fig|1352941.4.peg.6956; -.
DR eggNOG; COG2241; Bacteria.
DR eggNOG; COG2242; Bacteria.
DR HOGENOM; CLU_031955_1_0_11; -.
DR OrthoDB; 4327941at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000017971; Chromosome.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR012818; CbiE.
DR InterPro; IPR006365; Cbl_synth_CobL.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR02467; CbiE; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036428; CobL; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EST20392.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EST20392.1}.
FT DOMAIN 15..182
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 406 AA; 42199 MW; 4CE9D2EBC9B4D726 CRC64;
MADRVTVIGW DGSPLAPAAT SALAAATLVA GAAHHLALPE VPQDAERIRL GSVDLAARRI
AGHRGSAVVL ADGDPGFFGV VRTLRAPEHG LEVEVVPAVS AVATAFARAG MPWDDAQIVV
AQQRTLRRAV NVCRAHTKVA VLTSPGAGPA ELALLLQGVH RTFVICEELG TDREQVTVLT
SDKAADHVWR DPNVVIVVGG IGTAPVRTGG WIAGHDPEFP PAVRGWALPS EEYGIDLDEG
ESTWLRAAQL ARLGARTGDL VWDIGSGSGA LAAEAGRFGA AVIAVDAEPG ACASTAAAAR
RAGVQLEVVE GRAPHVLENL PEPDVVRIGG GGVDVVVACA DRRPARIVTH AATRDEAEAV
CTALREGGYV VECVLLQSVE MDTGAWSERE RSVVFLVSGS RPDRAP
//
