ID V6JLC8_STRRC Unreviewed; 674 AA.
AC V6JLC8;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=phospholipase C {ECO:0000256|ARBA:ARBA00012018};
DE EC=3.1.4.3 {ECO:0000256|ARBA:ARBA00012018};
GN ORFNames=M878_40865 {ECO:0000313|EMBL:EST19926.1};
OS Streptomyces roseochromogenus subsp. oscitans DS 12.976.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352936 {ECO:0000313|EMBL:EST19926.1, ECO:0000313|Proteomes:UP000017984};
RN [1] {ECO:0000313|EMBL:EST19926.1, ECO:0000313|Proteomes:UP000017984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS 12.976 {ECO:0000313|EMBL:EST19926.1,
RC ECO:0000313|Proteomes:UP000017984};
RX PubMed=24407645;
RA Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS
RT 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin.";
RL Genome Announc. 2:e01147-e01113(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:10604,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:295975; EC=3.1.4.3;
CC Evidence={ECO:0000256|ARBA:ARBA00023550};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10605;
CC Evidence={ECO:0000256|ARBA:ARBA00023550};
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004191}.
CC -!- SIMILARITY: Belongs to the bacterial phospholipase C family.
CC {ECO:0000256|ARBA:ARBA00009717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST19926.1}.
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DR EMBL; AWQX01000365; EST19926.1; -; Genomic_DNA.
DR RefSeq; WP_023553000.1; NZ_CM002285.1.
DR AlphaFoldDB; V6JLC8; -.
DR STRING; 1352936.M878_40865; -.
DR PATRIC; fig|1352936.5.peg.8464; -.
DR HOGENOM; CLU_008770_1_0_11; -.
DR OrthoDB; 4181857at2; -.
DR Proteomes; UP000017984; Chromosome.
DR GO; GO:0034480; F:phosphatidylcholine phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR017767; Bact_PC-PLC.
DR InterPro; IPR007312; Phosphoesterase.
DR InterPro; IPR008475; PLipase_C_C.
DR InterPro; IPR006311; TAT_signal.
DR NCBIfam; TIGR03396; PC_PLC; 1.
DR PANTHER; PTHR31956:SF8; ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570); 1.
DR PANTHER; PTHR31956; NON-SPECIFIC PHOSPHOLIPASE C4-RELATED; 1.
DR Pfam; PF04185; Phosphoesterase; 1.
DR Pfam; PF05506; PLipase_C_C; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Reference proteome {ECO:0000313|Proteomes:UP000017984};
KW Secreted {ECO:0000256|ARBA:ARBA00022512};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 472..569
FT /note="Bacterial phospholipase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05506"
FT DOMAIN 582..664
FT /note="Bacterial phospholipase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05506"
SQ SEQUENCE 674 AA; 72202 MW; 7D0151B83FB70827 CRC64;
MTPISRRGFV GLGASVAAGV ALGAGTRTDA AAATTATGTI KDVQHVVILM QENRSFDHYF
GRLKGVRGFD DRSGITLSGG FPVFNQPNGL GRQYPWKLSA TPDAGGKDGE TLAQCNGDLP
HSWSSQHSAW NKGRMDNWVS GVGNVRSLGY LDRSDIPFHY ALADNYTICD AYFCSTLSAT
GPNRTFLWSG KVDSSSYDGG DESGLTWQTY AEALQAAGVT WKVYQNAADN YGDNGCAYFK
NFANAKAGDP LYERGMSSVP KVTGSTPDDI AAAIKADVLA GTLPQVSWVV PNQAFSEHPY
APPGDGAHFV NLVYQALAAD QDVFDSTVLF LNYDENDGYF DHVPPPAPPA GTAGEFLNGV
PYGFGFRVPM LVISPWTRGG WVSSEVFEHT SVLRFLETWT SALGTPAQCA NISDWRRKVS
GDLTGVFDFA NPVYGSVSLP ATSVIGIDTC GPLPNPVPTD NALPAQEPGT RPSRALPYQP
GGYLDHLEFD AAGKILAWFT MTNQGAPASR AAHFSIHPNA YRDTTPFQYT VDPGGTASDF
FNIGTGFGGG KYDLTMVGPN RFLRRFQGDA TKPGKSAEVS TRYAVEPGTG KLAIYFKMTN
SGSAPVKFTI TSNHYRGDGP WTYTVAAGGS TEDYFNAVAY QNGWYDFTVT VDSDATWSRR
FTGRLETGAA GVSG
//
