ID V6JPI7_STRNV Unreviewed; 595 AA.
AC V6JPI7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Cell division protein {ECO:0000313|EMBL:EST21633.1};
GN ORFNames=M877_31440 {ECO:0000313|EMBL:EST21633.1};
OS Streptomyces niveus NCIMB 11891.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352941 {ECO:0000313|EMBL:EST21633.1, ECO:0000313|Proteomes:UP000017971};
RN [1] {ECO:0000313|EMBL:EST21633.1, ECO:0000313|Proteomes:UP000017971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCIMB 11891 {ECO:0000313|EMBL:EST21633.1,
RC ECO:0000313|Proteomes:UP000017971};
RX PubMed=24407644;
RA Flinspach K., Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the
RT Aminocoumarin Antibiotic Novobiocin.";
RL Genome Announc. 2:e01146-e01113(2014).
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST21633.1}.
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DR EMBL; AWQW01000228; EST21633.1; -; Genomic_DNA.
DR RefSeq; WP_023542364.1; NZ_CM002280.1.
DR AlphaFoldDB; V6JPI7; -.
DR STRING; 193462.BBN63_26140; -.
DR PATRIC; fig|1352941.4.peg.6389; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_6_5_11; -.
DR OrthoDB; 9789078at2; -.
DR Proteomes; UP000017971; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:EST21633.1};
KW Cell division {ECO:0000313|EMBL:EST21633.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 34..208
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 254..569
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 595 AA; 62800 MW; 4F8BD2AC207D21AE CRC64;
MLVFVVRLLQ VQAVDASAYT AKAEKNRFAS VTLAAERGDI TDRAGVALAT SVDAHDITAD
PKMFTPEDSN VADAPRQAAA LLAPILDKEP ETLAKQLSAP GSRFTVLAHR QTPQVWNQIK
DLKSVLAEKA DKARAAKGGK GDEAPASVLA GVFQEPSSKR VYPNGNLAAG ILGYVNAAGH
GGGGVESMFD ERLSGEDGEI TYAHSGGRRV PTAGSKETPA VPGTDIELTI DRDIQWAAQR
AISDQVAESE ADRGYVIVQN TRTGEVLAMA NAPGFDPNDL SQADSTSMGN AALQDAFEPG
STSKVMSMAA VLEEEAAVPG THVTVPNRLH RGDRLFKDDI DHPTWYLTLN GVLAKSSNIG
TILATGQLGK TQPQANQVLH SYLRKFGIGS PTGLNYPGET QGILADPKDW STSQQFTIPF
GQGLSVNAMQ AASVYSTIAN GGVRIEPTLV RGTEGPDGRF TPAPAPKKTR VVSEKTAKTL
SAMLESVVGD EAGTGTKARI PGYRVAGKTG TANRVDPETG RYKGYTASFA GFAPADDPQI
TVYCAIQNPT KGSYFGGQIC GPIYKEVMEF ALKSLQVPPT GKKSDPMPVE FKPGE
//
